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首页> 外文期刊>Annals of surgical oncology >Validation of the S classification of sentinel lymph node and microanatomic location of sentinel lymph node metastases to predict additional lymph node involvement and overall survival in breast cancer patients.
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Validation of the S classification of sentinel lymph node and microanatomic location of sentinel lymph node metastases to predict additional lymph node involvement and overall survival in breast cancer patients.

机译：前哨淋巴结的S分类和前哨淋巴结转移的微解剖位置的验证可预测乳腺癌患者中额外的淋巴结受累和总体生存。

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BACKGROUND: Most patients with a positive sentinel lymph node (SN) have no further metastases in the axillary lymph nodes and may therefore not benefit from axillary lymph node dissection. In patients with melanoma, evaluation of the centripetal depth of tumor invasion in the SN, also known as the S classification of SN, and microanatomic localization of SN metastases were shown to predict non-SN involvement. This phenomenon has been less extensively studied in breast cancer. We sought to validate the S classification and microanatomic location of SN metastases in breast cancer patients with regard to their predictive value for non-SN involvement and overall survival (OS). METHODS: A total of 236 patients with positive SN followed by axillary lymph node dissection were reevaluated according to the S classification and the microanatomic location of SN (subcapsular, parenchymal, combined subcapsular and parenchymal, multifocal, extensive) metastases to predict the likelihood of non-SN metastases and OS. RESULTS: S classification and the microanatomic location of SN metastases were significantly correlated with non-SN status (P < 0.001). Especially patients with a maximum depth of invasion
机译：背景：大多数前哨淋巴结（SN）阳性的患者在腋窝淋巴结无进一步转移，因此可能无法从腋窝淋巴结清扫中受益。在黑色素瘤患者中，评估SN中肿瘤侵犯的向心深度（也称为SN的S分类）和SN转移的微解剖定位可预测非SN的受累情况。这种现象在乳腺癌中的研究较少。我们试图验证乳腺癌患者中非SN参与和整体生存（OS）的预测价值的S分类和SN转移的微解剖位置。方法：根据S分类和SN（包膜下，实质，合并包膜下和实质，多灶性，广泛性）SN的微解剖位置，对236例SN阳性并随后腋窝淋巴结清扫术的患者进行重新评估，以预测非淋巴结转移的可能性。 -SN转移和OS。结果：S分类和SN转移的微解剖位置与非SN状态显着相关（P <0.001）。特别是最大浸润深度≤0.3mm（根据S分类为I期）且仅在囊下位置发生SN转移的患者发生进一步的非SN转移的可能性较低（分别为7.8％和6.1％）， OS的预后。结论：SN转移的S分类和显微解剖位置可预测非SN参与的可能性。尤其是具有囊下或I期转移的患者非SN转移的可能性低，并且OS的预后良好。

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