BRAF in Papillary Thyroid Carcinoma

Salvatore GiovanniLanzilotta; LucianoGrammatica; AngeloParadiso; GianniSimone

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BRAF in Papillary Thyroid Carcinoma

机译：乳头状甲状腺癌中的BRAF

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Novel genetic findings about papillary thyroid carcinoma identify BRAF gene as a subject of great interest. Involvement of BRAF gene in pathogenesis of PTC, diagnostic value and the putative prognostic significance of its T1799A mutation are summarized in this article. Furthermore, a particular attention is focused to the role of pre-operative detection of BRAF mutation in the FNAB specimens of thyroid nodules and to the use of this gene as target for an effective cancer therapy.

机译：关于甲状腺乳头状癌的新的遗传学发现将BRAF基因确定为一个重要课题。本文总结了BRAF基因在PTC的发病机制中的作用，其T1799A突变的诊断价值和预后的意义。此外，特别关注的是术前检测甲状腺结节的FNAB标本中BRAF突变的作用，以及将该基因用作有效癌症治疗的靶标。

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《Cellular Oncology: Analytical Cellular Pathology》 |2007年第4期|共9页
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Salvatore GiovanniLanzilotta; LucianoGrammatica; AngeloParadiso; GianniSimone;
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中图分类临床医学;
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1. BRAF and RAS Mutational Status in Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and Invasive Subtype of Encapsulated Follicular Variant of Papillary Thyroid Carcinoma in Korea [J] . Kim Mijin, Jeon Min Ji, Oh Hye-Seon, Thyroid: official journal of the American Thyroid Association . 2018,第4期

机译：BRAF和RAS突变状态在非耐磨卵泡甲状腺肿瘤中具有乳头状核特征和韩国乳头状甲状腺癌的封装滤泡变种的侵袭性亚型
2. Upregulation of TRIB2 by Wnt/beta-catenin activation in BRAF(V600E) papillary thyroid carcinoma cells confers resistance to BRAF inhibitor vemurafenib [J] . Wang Nianxue, Wen Jing, Ren Wei, Cancer chemotherapy and pharmacology. . 2021,第1期

机译：BRAF（V600E）乳头状甲状腺癌细胞上WNT /β-catenin活化的培训2对TRED2的上调赋予BRAF抑制剂vemureafenib的抗性
3. Malignant melanoma, papillary thyroid carcinoma and Erdheim–Chester disease, associated with both BRAF V600E BRAF V600E V600E and mosaic Turner syndrome [J] . Clinical and experimental dermatology . 2020,第4期

机译：恶性黑素瘤，乳头状甲状腺癌和Erdheim-Chester疾病，与BRAF V600E BRAF V600E和马赛克变型综合征有关
4. Coexistence of Medullary Carcinoma and Papillary Carcinoma in the Same Lobe of the Thyroid: A Rare Case Report [C] . Qiang Zhang, Yaoqi Wang, Xianying Meng, International Conference on Information Technology in Medicine and Education . 2016

机译：甲状腺同一叶中的髓样癌和乳头状癌共存：罕见病例报告
5. Immune infiltrates in papillary thyroid carcinomas. [D] . Kang, Kate Yuri. 2012

机译：甲状腺乳头状癌的免疫浸润。
6. A Case of Multifocal Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant with BRAF K601E Mutation and Three Conventional Types with BRAF V600E Mutation [O] . Wook Youn Kim, Young Sin Ko, Tae Sook Hwang, 2013

机译：一例包含BRAF K601E突变的囊化卵泡变体和BRAF V600E突变的三种常规类型的多灶性乳头状甲状腺癌一例
7. BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas [O] . NIKIFOROVA MN, KIMURA ET, GANDHI M, 2003

机译：甲状腺肿瘤中的BRAF突变仅限于乳头状癌和由乳头状癌引起的间变性或低分化癌

BRAF in Papillary Thyroid Carcinoma

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