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首页> 外文期刊>Cellular Oncology: Analytical Cellular Pathology >The Reproducibility of Nuclear Morphometric Measurements in Invasive Breast Carcinoma
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The Reproducibility of Nuclear Morphometric Measurements in Invasive Breast Carcinoma

机译：核形态计量学测量在浸润性乳腺癌中的可重复性

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The intraobserver and interobserver reproducibility of computerized nuclear morphometry was determined in repeated measurements of 212 samples of invasive breast cancer. The influence of biological variation and the selection of the measurement area was also tested. Morphometrically determined mean nuclear profile area (Pearson’sr0.89, grading efficiency (GE) 0.95) and standard deviation (SD) of nuclear profile area (Pearson’sr0.84, GE 0.89) showed high reproducibility. In this respect, nuclear morphometry equals with other established methods of quantitative pathology and exceeds the results of subjective grading of nuclear atypia in invasive breast cancer. A training period of eight days was sufficient to produce clear improvement in consistency of nuclear morphometry results. By estimating the sources of variation it could be shown that the variation associated with the measurement procedure itself is small. Instead, sample associated variation is responsible for the majority of variation in the measurements (82.9% in mean nuclear profile area and 65.9% in SD of nuclear profile area). This study points out that when standardized methods are applied computerized morphometry is a reproducible and reliable method of assessing nuclear atypia in invasive breast cancer. For further improvement special emphasize should be put on sampling rules of selecting the microscope fields and measurement areas.
机译：在重复测量212例浸润性乳腺癌样品中，确定了计算机核形态学的观察者内和观察者间可重复性。还测试了生物变异的影响和测量区域的选择。经形态计量学确定的平均核分布面积（皮尔逊sr0.89，分级效率（GE）0.95）和核分布面积标准偏差（SD）（皮尔森sr0.84，GE 0.89）显示出高重复性。在这方面，核形态学与其他已建立的定量病理学方法相当，并且超过了浸润性乳腺癌中核异型的主观分级结果。八天的培训时间足以明显改善核形态测量结果的一致性。通过估计变化的来源，可以表明与测量过程本身相关的变化很小。取而代之的是，与样品相关的变化是测量中大多数变化的原因（平均核剖面面积的82.9％和核剖面面积的SD的65.9％）。这项研究指出，当应用标准化方法时，计算机形态计量学是评估浸润性乳腺癌中核非典型性的可再现且可靠的方法。为了进一步改进，应特别注意选择显微镜视野和测量区域的采样规则。

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