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The Reproducibility of Nuclear Morphometric Measurements in Invasive Breast Carcinoma

机译：侵袭性乳腺癌核形态测量的再现性

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摘要

The intraobserver and interobserver reproducibility of computerized nuclear morphometry was determined in repeated measurements of 212 samples of invasive breast cancer. The influence of biological variation and the selection of the measurement area was also tested. Morphometrically determined mean nuclear profile area (Pearson’s r 0.89, grading efficiency (GE) 0.95) and standard deviation (SD) of nuclear profile area (Pearson’s r 0.84, GE 0.89) showed high reproducibility. In this respect, nuclear morphometry equals with other established methods of quantitative pathology and exceeds the results of subjective grading of nuclear atypia in invasive breast cancer. A training period of eight days was sufficient to produce clear improvement in consistency of nuclear morphometry results. By estimating the sources of variation it could be shown that the variation associated with the measurement procedure itself is small. Instead, sample associated variation is responsible for the majority of variation in the measurements (82.9% in mean nuclear profile area and 65.9% in SD of nuclear profile area). This study points out that when standardized methods are applied computerized morphometry is a reproducible and reliable method of assessing nuclear atypia in invasive breast cancer. For further improvement special emphasize should be put on sampling rules of selecting the microscope fields and measurement areas.
机译：在212例侵入性乳腺癌样本的重复测量中确定了计算机核形态学的血管内的腹腔和interobserver再现性。还测试了生物变异的影响和测量区域的选择。形态化的平均核轮廓面积（Pearson的R 0.89，分级效率（GE）0.95）和核轮廓区域的标准偏差（SD）（Pearson的R 0.84，GE 0.89）显示出高再现性。在这方面，核形态学等于其他既定的定量病理方法，超过了侵袭性乳腺癌核原型的主观评级的结果。培训期为八天足以产生明显改善核形态学结果的一致性。通过估计变异源来源，可以示出与测量过程本身相关的变化很小。相反，样品相关变化对测量的大部分变化负责（平均核轮廓面积82.9％，SD在核轮廓区域的65.9％）。本研究指出，当应用标准化方法时，计算机化的形态学是一种可再现乳腺癌核原型的可再现和可靠的方法。有关进一步的改进，应特别强调选择显微镜场和测量区域的采样规则。

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