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首页> 外文期刊>Cellular Physiology and Biochemistry >Acute Kidney Injury Reduces Phagocytic and Microbicidal Capacities of Alveolar Macrophages
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Acute Kidney Injury Reduces Phagocytic and Microbicidal Capacities of Alveolar Macrophages

机译：急性肾脏损伤可减少肺泡巨噬细胞的吞噬和杀微生物能力

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biBackground/Aims /i/bRenal ischaemia-reperfusion injury (IRI) is a systemic inflammatory process in which Th1 responses predominate affecting other organs including the lungs. The present study explored the phagocytic and microbicidal capacity of macrophages in rats with lung inflammation that underwent IRI. biMethods /i/bThe alveolar macrophages of rats sensitised to OVA were evaluated for phagocytosis and bacterial killing 24h after antigen challenge in animals with or without prior submission to 60 min of renal ischaemia. biResults /i/bBronchoalveolar lavage had a high level of cellular infiltrate in immunised animals (420%) compared with control animals; IRI significantly reduced this infiltration (52%). Macrophages from animals immunised and challenged with OVA presented a 10x increase in phagocytic capacity compared to the control group, whereas immunised animals subjected to IRI showed a reduction in the phagocytic index of 68%. The killing of iKlebsiella pneumoniae /iby macrophages from immunised animals was higher (56%) compared with the control group but reduced in animals submitted to IRI (45%). Immunised and challenged group showed an increase in gene expression levels of IL-10(450%), HO-1 (259%), INF-γ (460%) and MCP-1 (370%) compared to the immunised group subjected to IRI. biConclusions /i/bRenal ischaemia and reperfusion injury apparently alters the phagocytic and microbicidal capacity of macrophages, reducing lung inflammation to OVA.
机译：背景/目标 肾缺血/再灌注损伤（IRI）是一种全身性炎症过程，其中Th1反应主要影响其他器官，包括肺。本研究探讨了接受IRI的肺部炎症大鼠巨噬细胞的吞噬和杀微生物能力。 方法 评估了对OVA致敏的大鼠的肺泡巨噬细胞在抗原攻击后24h内是否吞噬和杀死细菌，无论是否接受肾缺血60分钟。 结果 与对照动物相比，免疫动物中支气管肺泡灌洗液的细胞浸润水平较高（420％）; IRI显着减少了这种渗透（52％）。与对照组相比，OVA免疫和攻击的动物的巨噬细胞吞噬能力提高了10倍，而接受IRI免疫的动物的吞噬指数降低了68％。与对照组相比，被免疫动物的巨噬细胞对肺炎克雷伯菌的杀死率更高（56％），但在接受IRI的动物（45％）中则有所降低。免疫和攻击组显示IL-10（450％），HO-1（259％），INF-＆＃947的基因表达水平增加; （460％）和MCP-1（370％）相较于接受IRI的免疫组。 结论 肾缺血和再灌注损伤显然改变了巨噬细胞的吞噬能力和杀微生物能力，从而降低了OVA引起的肺部炎症。

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