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首页> 外文期刊>Cell death & disease. >Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment
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Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment

机译：禁止素域家族在肿瘤发生中的意义及其在癌症诊治中的意义

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Prohibitin (PHB) was originally isolated and characterized as an anti-proliferative gene in rat liver. The evolutionarily conserved PHB gene encodes two human protein isoforms with molecular weights of ~33?kDa, PHB1 and PHB2. PHB1 and PHB2 belong to the prohibitin domain family, and both are widely distributed in different cellular compartments such as the mitochondria, nucleus, and cell membrane. Most studies have confirmed differential expression of PHB1 and PHB2 in cancers compared to corresponding normal tissues. Furthermore, studies verified that PHB1 and PHB2 are involved in the biological processes of tumorigenesis, including cancer cell proliferation, apoptosis, and metastasis. Two small molecule inhibitors, Rocaglamide (RocA) and fluorizoline, derived from medicinal plants, were demonstrated to interact directly with PHB1 and thus inhibit the interaction of PHB with Raf-1, impeding Raf-1/ERK signaling cascades and significantly suppressing cancer cell metastasis. In addition, a short peptide ERAP and a natural product xanthohumol were shown to target PHB2 directly and prohibit cancer progression in estrogen-dependent cancers. As more efficient biomarkers and targets are urgently needed for cancer diagnosis and treatment, here we summarize the functional role of prohibitin domain family proteins, focusing on PHB1 and PHB2 in tumorigenesis and cancer development, with the expectation that targeting the prohibitin domain family will offer more clues for cancer therapy.
机译：抑制素（PHB）最初是分离的，并被表征为大鼠肝脏中的抗增殖基因。进化上保守的PHB基因编码分子量约为33？kDa的两种人蛋白质同工型，PHB1和PHB2。 PHB1和PHB2属于禁止素结构域家族，并且都广泛分布在不同的细胞区室中，例如线粒体，细胞核和细胞膜。大多数研究已经证实，与相应的正常组织相比，PHB1和PHB2在癌症中的差异表达。此外，研究证实PHB1和PHB2参与肿瘤发生的生物学过程，包括癌细胞的增殖，凋亡和转移。已证明两种药用植物的小分子抑制剂Rocaglamide（RocA）和氟唑啉直接与PHB1相互作用，从而抑制PHB与Raf-1的相互作用，阻止Raf-1 / ERK信号级联反应并显着抑制癌细胞转移。此外，短肽ERAP和天然产物黄腐酚被证明直接靶向PHB2，并在雌激素依赖性癌症中阻止癌症进展。由于迫切需要更有效的生物标志物和靶标进行癌症诊断和治疗，在这里我们总结禁止素域家族蛋白的功能，重点关注PHB1和PHB2在肿瘤发生和癌症发展中的作用，并期望靶向禁止素域家族将提供更多癌症治疗的线索。

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