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首页> 外文期刊>Cellular Physiology and Biochemistry >Tissue Vitamin A Insufficiency Results in Adverse Ventricular Remodeling after Experimental Myocardial Infarction
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Tissue Vitamin A Insufficiency Results in Adverse Ventricular Remodeling after Experimental Myocardial Infarction

机译：实验性心肌梗死后组织维生素A功能不足导致心室重构

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Background/Aims The role of tissue vitamin-A insufficiency on post-infarction ventricular remodeling is unknown. We tested the hypothesis that cardiac vitamin A insufficiency on post-infarction is associated with adverse myocardial remodeling. Methods After infarction, rats were allocated into two groups C (controls, n=25); VA (dietary vitamin A restriction, n= 26). After 3 months, the animals were submitted to echocardiogram, morphometric and biochemical analysis. Results Rats fed the vitamin-A-deficient diet had lower heart and liver retinol concentration and normal plasma retinol. There were no differences in infarct size between the groups. VA showed higher diastolic left ventricular area normalised by body weight (C= 1.81 ± 0.4 cm2/kg, VA= 2.15 ± 0.3 cm2/kg; p=0.03), left ventricular diameter (C= 9.4 ± 1.4 mm, VA= 10.5 ± 1.2 mm; p=0.04), but similar systolic ventricular fractional area change (C= 33.0 ± 10.0 %, VA= 32.1 ± 8.7 %; p=0.82). VA showed decreased isovolumetric relaxation time normalised by heart rate (C= 68.8 ± 11.4 ms, VA= 56.3 ± 16.8 ms; p=0.04). VA showed higher interstitial collagen fraction (C= 2.8 ± 0.9 %, VA= 3.7 ± 1.1 %; p=0.05). There were no differences in myosin heavy chain expression, metalloproteinase 2 and 9 activation, or IFN-γ and TNF-α cardiac levels. Conclusion Local tissue vitamin A insufficiency intensified ventricular remodeling after MI, worsening diastolic dysfunction.
机译：背景/目的组织维生素A功能不足对梗死后心室重构的作用尚不清楚。我们检验了以下假设，即心肌梗死后心脏维生素A功能不足与不良的心肌重塑有关。方法梗死后，将大鼠分为C组（对照组，n = 25），每组25只。 VA（饮食中维生素A限制，n = 26）。 3个月后，对动物进行超声心动图，形态测定和生化分析。结果饮食中缺乏维生素A的大鼠心脏和肝脏的视黄醇浓度较低，血浆视黄醇正常。两组之间的梗死面积无差异。 VA显示较高的舒张期左心室面积通过体重标准化（C = 1.81±0.4 cm2 / kg，VA = 2.15±0.3 cm2 / kg; p = 0.03），左心室直径（C = 9.4±1.4 mm，VA = 10.5± 1.2 mm; p = 0.04），但收缩期心室分数变化类似（C = 33.0±10.0％，VA = 32.1±8.7％; p = 0.82）。 VA表现出等速舒张时间的减少（通过心率归一化）（C = 68.8±11.4 ms，VA = 56.3±16.8 ms; p = 0.04）。 VA显示较高的间质胶原蛋白含量（C = 2.8±0.9％，VA = 3.7±1.1％; p = 0.05）。肌球蛋白重链表达，金属蛋白酶2和9激活或IFN-γ和TNF-α心脏水平无差异。结论MI后局部组织维生素A不足会加剧心室重构，加重舒张功能障碍。

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