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agent for treating myocardial infarction and suppressing left ventricular remodeling after myocardial infarction and use of il-6 inhibitor
agent for treating myocardial infarction and suppressing left ventricular remodeling after myocardial infarction and use of il-6 inhibitor
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机译:心肌梗死后抑制心肌梗塞和抑制左心室重构的药物和il-6抑制剂的使用
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摘要
B AGENT TO TREAT MYOCARDIAL INFARCTION AND TO SUPPRESS LEFT VENTRICULAR REMODELING AFTER MYOCARDIAL INFARCTION AND USE OF THE IL-6 INHIBITOR D The present invention relates to the effects of anti-IL-6 receptor antibodies on improving the condition of infarcted areas in myocardial infarction, and in suppressing left ventricular remodeling after myocardial infarction. As a result, administration of anti-IL-6 receptor antibodies significantly suppressed the increase in MPO activity in the infarcted area and suppressed myocardial MCP-1 expression in both the infarcted and non-infarcted areas. In addition, echocardiographic and histological examinations revealed that cardiac hypertrophy is also suppressed.
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