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首页> 外文期刊>Cellular Physiology and Biochemistry >Sphingosine 1-Phosphate in Blood: Function, Metabolism, and Fate
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Sphingosine 1-Phosphate in Blood: Function, Metabolism, and Fate

机译：血液中的鞘氨醇1-磷酸：功能，代谢和命运

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Sphingosine 1-phosphate (S1P) is a lipid metabolite and a ligand of five G protein-coupled cell surface receptors S1PR1 to S1PR5. These receptors are expressed on various cells and cell types of the immune, cardiovascular, respiratory, hepatic, reproductive, and neurologic systems, and S1P has an impact on many different pathophysiological conditions including autoimmune, cardiovascular, and neurodegenerative diseases, cancer, deafness, osteogenesis, and reproduction. While these diverse signalling properties of S1P have been extensively reviewed, the particular role of S1P in blood is still a matter of debate. Blood contains the highest S1P concentration of all body compartments, and several questions are still not sufficiently answered Where does it come from and how is it metabolized? Why is the concentration of S1P in blood so high? Are minor changes of the high blood S1P concentrations physiologically relevant? Do blood cells and vascular endothelial cells that are constantly exposed to high blood S1P levels still respond to S1P via S1P receptors? Recent data reveal new insights into the functional role and the metabolic fate of blood-borne S1P. This review aims to summarize our current knowledge regarding the source, secretion, transportation, function, metabolism, and fate of S1P in blood.
机译：1-磷酸鞘氨醇（S1P）是一种脂质代谢产物，是5种G蛋白偶联的细胞表面受体S1PR1至S1PR5的配体。这些受体在免疫，心血管，呼吸，肝，生殖和神经系统的各种细胞和细胞类型上表达，S1P对许多不同的病理生理状况都有影响，包括自身免疫，心血管和神经退行性疾病，癌症，耳聋，成骨和复制。尽管已经广泛审查了S1P的这些多样的信号传导特性，但S1P在血液中的特殊作用仍是一个有争议的问题。血液中所有车厢中的S1P浓度最高，仍然没有充分回答几个问题，它来自何处以及如何代谢？为什么血液中S1P的浓度如此之高？高血S1P浓度的微小变化是否与生理相关？经常暴露于高血S1P水平的血细胞和血管内皮细胞是否仍通过S1P受体对S1P作出反应？最近的数据揭示了对血源性S1P的功能作用和代谢命运的新见解。这篇综述旨在总结我们目前关于血液中S1P的来源，分泌，运输，功能，代谢和命运的知识。

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