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首页> 外文期刊>Cellular Physiology and Biochemistry >Mining Prognostic Significance of MEG3 in Human Breast Cancer Using Bioinformatics Analysis
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Mining Prognostic Significance of MEG3 in Human Breast Cancer Using Bioinformatics Analysis

机译：利用生物信息学分析挖掘MEG3在乳腺癌中的预后意义

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Background/Aims Maternally expressed gene 3 (MEG3) is an imprinted gene with maternal expression, which may function as a tumor suppressor by inhibiting angiogenesis. To identify the prognostic value of MEG3 in breast cancer, systematic analysis was performed in this study. Methods To evaluate gene alteration during breast carcinogenesis, we explored MEG3 expression using the Serial Analysis of Gene Expression Genie suite and Oncomine analysis. The prognostic roles of MEG3 in breast cancer were investigated using the PrognoScan database. The heat map and methylation status of MEG3 were determined using the UCSC Genome Browser. Results We found that MEG3 was more frequently downregulated in breast cancer than in normal tissues and this correlated with prognosis. However, estrogen receptor and progesterone receptor status were found to be positively correlated with MEG3 expression. Conversely, basal-like status, triple-negative breast cancer status, and Scarff Bloom & Richardson grade criterion were negatively correlated with MEG3 expression. Following data mining in multiple big data databases, we confirmed a positive correlation between MEG3 and heparan sulfate proteoglycan 2 (HSPG2) expression in breast cancer tissues. Conclusion MEG3 could be adopted as a marker to predict the prognosis of breast cancer with HSPG2. However, large-scale and comprehensive research is needed to clarify our results.
机译：背景/目的母体表达基因3（MEG3）是一种印有母体表达的基因，可通过抑制血管生成而发挥抑癌作用。为了确定MEG3在乳腺癌中的预后价值，在这项研究中进行了系统的分析。方法为了评估乳癌发生过程中的基因改变，我们使用基因表达精灵套件的序列分析和Oncomine分析探索了MEG3的表达。使用PrognoScan数据库调查了MEG3在乳腺癌中的预后作用。使用UCSC Genome Browser确定MEG3的热图和甲基化状态。结果我们发现，MEG3在乳腺癌中比在正常组织中更频繁地被下调，这与预后相关。然而，发现雌激素受体和孕激素受体的状态与MEG3表达呈正相关。相反，基底样状态，三阴性乳腺癌状态和Scarff Bloom＆＃38;理查森分级标准与MEG3表达负相关。在多个大数据数据库中进行数据挖掘之后，我们证实了MEG3与乳腺癌组织中的硫酸乙酰肝素蛋白聚糖2（HSPG2）表达呈正相关。结论MEG3可作为HSPG2预测乳腺癌预后的指标。但是，需要大规模和全面的研究来阐明我们的结果。

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