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首页> 外文期刊>Cellular Physiology and Biochemistry >Upregulated Serum MiR-146b Serves as a Biomarker for Acute Ischemic Stroke
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Upregulated Serum MiR-146b Serves as a Biomarker for Acute Ischemic Stroke

机译：上调的血清MiR-146b作为急性缺血性中风的生物标志物

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Background/Aims Stroke is a major cerebrovascular disease threatening human health and life with high morbidity, disability and mortality. It is aimed to find effective biomarkers for the early diagnosis on stroke. Methods The expressions of 17 previously reported stroke-associated miRNAs were measured using quantitative RT-PCR and the expressions of plasma high-sensitivity C reactive protein (hs-CRP) and serum interleukin 6 (IL-6), the pro-inflammation markers in brain injury, were examined using enzyme-linked immunosorbent assay in 128 acute ischemic stroke (AIS) patients and control group. Results Serum miR-146b expression was significantly increased within 24 hours after stroke onset in patients compared with control group. In addition, the upregulation of serum miR-146b was strong positively correlated with plasma hs-CRP, infarct volume and National Institutes of Health Stroke Scale (NIHSS) score, and moderate positively correlated with serum IL-6 of patients. Importantly, the combination of plasma hs-CRP and serum miR-146b gained a better sensitivity/specificity for prediction of AIS (AUC from 0.782 to 0.863). Conclusion Our preliminary findings suggested that upregulated serum miR-146b in acute ischemic stroke might be a potential biomarker for AIS evaluation.
机译：背景/目的中风是一种主要的脑血管疾病，具有很高的发病率，致残率和死亡率，威胁着人类的健康和生命。目的是寻找有效的生物标志物，以对中风进行早期诊断。方法采用定量RT-PCR方法检测17例卒中相关miRNA的表达，并检测血浆高敏C反应蛋白（hs-CRP）和血清白细胞介素6（IL-6）的表达。使用酶联免疫吸附法对128例急性缺血性中风（AIS）患者和对照组的脑损伤进行了检查。结果与对照组相比，中风发作后24小时内患者血清miR-146b表达明显升高。此外，血清miR-146b的上调与血浆hs-CRP，梗死体积和国立卫生研究院卒中量表（NIHSS）评分呈正相关，与患者血清IL-6呈正相关。重要的是，血浆hs-CRP和血清miR-146b的组合对于AIS的预测具有更好的敏感性/特异性（AUC从0.782至0.863）。结论我们的初步发现提示急性缺血性卒中中血清miR-146b可能是AIS评估的潜在生物标志物。

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