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首页> 外文期刊>Cellular Physiology and Biochemistry >Expression of PITX2 Homeodomain Transcription Factor during Rat Gonadal Development in a Sexually Dimorphic Manner
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Expression of PITX2 Homeodomain Transcription Factor during Rat Gonadal Development in a Sexually Dimorphic Manner

机译：大鼠性腺发育过程中性二态性表达PITX2同源域转录因子的表达。

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PITX2, a multifunctional Paired-like homeodomain transcription factor, plays obligatory role during development of organs like heart, brain and pituitary. It regulates differentiation of vascular smooth muscle cells and hematopoietic stem cells. Although we earlier reported the iPitx2//iPITX2 expression in gonad, but the expression pattern of its different isoforms in mammalian gonads especially during development is still not known. As PITX2 participates in the development of multiple organs and different homeobox genes have been shown to control gonadal functions, we wanted to investigate the role of PITX2 in gonadal development and its function. The objective of our study was to know the expression profile of different iPitx2//iPITX2 isoforms and its localization throughout the development of gonads. Here we show the temporal and spatial expression pattern of iPitx2//iPITX2 and its localization throughout the embryonic and postnatal stages of rat gonads. iPitx2//iPITX2 expression profile reveals the differential and dimorphic expression pattern of its two isoforms PITX2B2 and-Cβ throughout the embryonic development stages and also in the postnatal stages, where it becomes more prominent. This is the first report where PITX2 homeodomain transcription factor shows isoform-specific sexually dimorphic expression. In addition, PITX2 localization was found in the embryonic ovarian primordial germ cell clusters and germ cells inside the testicular cords and also in somatic cells. In adults, ovarian granulosa and theca cells as well as germ cells inside the seminiferous tubules in testis express PITX2. All the evidences suggest that the differential expression of PITX2 might be associated with sex-specific embryonic and postnatal gonadal development and the physiological processes.
机译：PITX2是一种多功能成对的同源域转录因子，在心脏，大脑和垂体等器官发育过程中起着必不可少的作用。它调节血管平滑肌细胞和造血干细胞的分化。尽管我们早些时候报道了性腺中 Pitx2 / PITX2的表达，但是在哺乳动物性腺中，特别是在发育过程中，其不同亚型的表达模式仍然未知。由于PITX2参与了多个器官的发育，并且已经显示出不同的同源盒基因可控制性腺功能，因此我们想研究PITX2在性腺发育中的作用及其功能。我们研究的目的是了解不同的 Pitx2 / PITX2亚型的表达谱及其在性腺发育过程中的定位。在这里，我们显示了 Pitx2 / PITX2的时空表达模式及其在大鼠性腺的整个胚胎和出生后阶段的定位。 Pitx2 / PITX2表达谱揭示了其两个同工型PITX2B2和-Cβ在整个胚胎发育阶段以及出生后阶段的差异和双态表达模式，在该阶段它变得更加突出。这是PITX2同源域转录因子显示同工型特异性性二态表达的第一个报告。此外，PITX2定位存在于胚胎卵巢原始生殖细胞簇和睾丸内的生殖细胞以及体细胞中。在成年人中，卵巢颗粒和卵泡膜细胞以及睾丸生精小管内的生殖细胞表达PITX2。所有证据表明，PITX2的差异表达可能与性别特异性的胚胎和出生后的性腺发育以及生理过程有关。

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