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首页> 外文期刊>Cellular Physiology and Biochemistry >Interleukin-2 and Interleukin-8 Gene Polymorphisms and Acquired Aplastic Anemia Risk in a Chinese Population
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Interleukin-2 and Interleukin-8 Gene Polymorphisms and Acquired Aplastic Anemia Risk in a Chinese Population

机译：白细胞介素2和白细胞介素8基因多态性和获得性再生障碍性贫血的风险在中国人口中。

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>Background/Aims: Cytokines IL-2 and IL-8 both participate in immune regulation. However, the relationship between polymorphisms in these two cytokines and the risk of acquired aplastic anemia (acquired AA) has not been explored. Methods: We selected five SNPs including rs11575812, rs2069772 and rs2069762 of IL-2, rs2227306 and rs2227543 of IL-8. SNaPshot genotyping was used to test the genotypes of IL-2 and IL-8 polymorphisms in a population of 101 acquired AA patients and 165 healthy controls. Results: The rs2069762 G allele appeared to be a protective mutation, but no significant differences were found in other four SNPs. We also found that rs2069762 had an impact on the transcriptional regulation. Conclusions: It could be assumed that the rs2069762 polymorphism might reduce the risk of acquired aplastic anemia, while the remaining four SNPs might not contribute to susceptibility to acquired AA in a Chinese population.
机译：> 背景/目的： 细胞因子IL-2和IL-8均参与免疫调节。但是，这两种细胞因子中的多态性与获得性再生障碍性贫血（获得性AA）的风险之间的关系尚未探索。 方法： 我们选择了5个SNP，包括IL-2的rs11575812，rs2069772和rs2069762，IL-8的rs2227306和rs2227543。 SNaPshot基因分型用于测试101例获得性AA患者和165名健康对照人群中IL-2和IL-8多态性的基因型。 结果： rs2069762 G等位基因似乎是一个保护性突变，但在其他四个SNP中未发现显着差异。我们还发现rs2069762对转录调控有影响。 结论： 可以假设rs2069762多态性可能会降低获得性再生障碍性贫血的风险，而其余四个SNP可能对中国人群对获得性AA的易感性没有贡献。

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