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首页> 外文期刊>Cell Reports >Serotonergic versus Nonserotonergic Dorsal Raphe Projection Neurons: Differential Participation in Reward Circuitry
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Serotonergic versus Nonserotonergic Dorsal Raphe Projection Neurons: Differential Participation in Reward Circuitry

机译：血清素能与非血清素能的背缝投射神经元：参与奖励电路的差异性。

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The dorsal raphe nucleus (DRN) contains the largest group of serotonin-producing neurons in the brain and projects to regions controlling reward. Although pharmacological studies suggest that serotonin inhibits reward seeking, electrical stimulation of the DRN strongly reinforces instrumental behavior. Here, we provide a targeted assessment of the behavioral, anatomical, and electrophysiological contributions of serotonergic and nonserotonergic DRN neurons to reward processes. To explore DRN heterogeneity, we used a simultaneous two-vector knockout/optogenetic stimulation strategy, as well as cre-induced and cre-silenced vectors in several cre-expressing transgenic mouse lines. We found that the DRN is capable of reinforcing behavior primarily via nonserotonergic neurons, for which the main projection target is the ventral tegmental area (VTA). Furthermore, these nonserotonergic projections provide glutamatergic excitation of VTA dopamine neurons and account for a large majority of the DRN-VTA pathway. These findings help to resolve apparent discrepancies between the roles of serotonin versus the DRN in behavioral reinforcement.
机译：背缝核（DRN）包含大脑中最多的一组产生血清素的神经元，并投射到控制奖赏的区域。尽管药理研究表明，5-羟色胺会抑制寻求奖励，但DRN的电刺激会强烈增强器械行为。在这里，我们提供了对血清素能和非血清素能DRN神经元在奖励过程中的行为，解剖和电生理的有针对性的评估。为了探索DRN的异质性，我们在多个表达cre的转基因小鼠品系中使用了同时的两个载体敲除/光遗传刺激策略，以及cre诱导和cre沉默的载体。我们发现DRN能够主要通过非血清素能神经元来增强行为，为此，主要投射目标是腹侧被盖区（VTA）。此外，这些非5-羟色胺能投射提供了VTA多巴胺神经元的谷氨酸能激发，并占了DRN-VTA途径的绝大部分。这些发现有助于解决5-羟色胺与DRN在行为强化中的作用之间的明显差异。

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