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Study of HSPB6: Insights into the Properties of the Multifunctional Protective Agent

机译：HSPB6研究：多功能保护剂性能的见解

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>HSPB6(Heat shock protein B6), is also referred to as P20/HSP20. Unlike other many other members of sHSP(small Heat shock protein) family, which tend to form high-molecular-mass oligomers, in solution, human HSPB6 only forms dimers. However, it still exhibits chaperon-like activity comparable with that of HSPB5. It is expressed ubiquitously, with high and constitutive expression in muscular tissues. sHSPs characteristically function as molecular chaperones and HSPB6 also has a molecular chaperone activity. HSPB6 is up-regulated in response to diverse cellular stress or damage and protect cells from otherwise lethal conditions. HSPB6 is widely recognized as a principle mediator of cardioprotective signaling and recent studies have unraveled the protective role of HSPB6 in disease or injury to the central nervous system. Moreover, accumulating evidence has implicated HSPB6 as a key mediator of diverse vital physiological processes, such as smooth muscle relaxation, platelet aggregation. The versatility of HSPB6 can be explained by its direct involvement in regulating different client proteins and its ability to form heterooligomer with other sHSPs, which seems to be dependent on HSPB6 phosphorylation. This review focuses on the properties including expression and regulation pattern, phosphorylation, chaperon activity, multiple cellular targets of HSPB6, as well as its possible role in physical and pathological conditions.
机译：HSPB6（热激蛋白B6），也称为P20 / HSP20。不同于在溶液中易于形成高分子质量低聚物的sHSP（小型热激蛋白）家族的其他成员，人HSPB6仅形成二聚体。然而，它仍然表现出与HSPB5相当的伴侣状活性。它在肌肉组织中普遍表达，并具有高水平和组成型表达。 sHSPs具有分子伴侣的功能，HSPB6也具有分子伴侣的活性。 HSPB6被上调以响应各种细胞应激或损伤，并保护细胞免受其他致命条件的伤害。 HSPB6被广泛认为是心脏保护信号的主要介体，最近的研究揭示了HSPB6在疾病或中枢神经系统损伤中的保护作用。此外，越来越多的证据表明HSPB6是多种重要生理过程（如平滑肌松弛，血小板聚集）的关键介体。 HSPB6的多功能性可以通过其直接参与调节不同的客户蛋白质，以及与其他sHSP形成异源寡聚体的能力来解释，这似乎取决于HSPB6的磷酸化作用。这篇综述着重于特性，包括表达和调控模式，磷酸化，分子伴侣活性，HSPB6的多个细胞靶标及其在物理和病理条件下的可能作用。

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