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首页> 外文期刊>Cell Reports >IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation
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IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation

机译：IRF-7是过敏性气道炎症中2型先天淋巴细胞的关键调节剂。

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Allergic asthma is a highly prevalent airway disease triggered by hyperresponsiveness to inhaled allergens. Interferon regulatory factor 7 (IRF7) has been shown to be highly expressed in nasal aspirates from children with asthma. Type 2 innate lymphoid cells (ILC2s) represent the major player in allergic airway inflammation. The role of IRF7 in ILC2-driven asthma remains to be explored. Here, we report that IRF7 expression in murine lung ILC2s is dramatically induced upon papain or interleukin-33 (IL-33) stimulation. ILC2s from asthma patients display a much higher level of IRF7 than those from healthy donors. Deficiency of IRF7 in mice significantly impairs the expansion and function of lung ILC2s in multiple models of allergic asthma. Furthermore, the regulation of ILC2s by IRF7 is cell intrinsic and mediated by the transcription factor Bcl11b. These observations identify IRF7 as a regulator of lung ILC2s, which?may have immunotherapeutic value in allergic asthma.
机译：过敏性哮喘是一种高度流行的呼吸道疾病，由对吸入的过敏原的过度反应引发。业已证明，干扰素调节因子7（IRF7）在患有哮喘的儿童的鼻吸物中高表达。 2型先天淋巴样细胞（ILC2）代表了过敏性气道炎症的主要因素。 IRF7在ILC2驱动的哮喘中的作用仍有待探索。在这里，我们报道木瓜蛋白酶或白介素33（IL-33）刺激后，小鼠肺ILC2s中的IRF7表达被大大诱导。来自哮喘患者的ILC2的IRF7水平要比来自健康供体的ILC2高得多。在多种过敏性哮喘模型中，小鼠IRF7的缺乏显着削弱了肺ILC2的扩增和功能。此外，IRF7对ILC2的调节是细胞内在的，并由转录因子Bcl11b介导。这些观察结果表明IRF7是肺ILC2的调节剂，可能在过敏性哮喘中具有免疫治疗价值。

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