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首页> 外文期刊>Ceylon Medical Journal >Effects of 5 IU oxytocin bolus and 20 IU oxytocin infusion compared to 5 IU oxytocin bolus and normal saline infusion in the control of blood loss during and after ante-partum lower segment caesarean section: a randomized controlled trial
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Effects of 5 IU oxytocin bolus and 20 IU oxytocin infusion compared to 5 IU oxytocin bolus and normal saline infusion in the control of blood loss during and after ante-partum lower segment caesarean section: a randomized controlled trial

机译：5 IU催产素推注和20 IU催产素输注与5 IU催产素推注和生理盐水输注相比对控制产前下节剖腹产前后出血的控制效果：一项随机对照试验

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Introduction Obstetric haemorrhage is the leading cause of maternal mortality worldwide and in most cases it relates to uterine atony. Even though an oxytocin bolus is used routinely, additional infusion of oxytocin may be required if haemorrhage occurs. Objectives To compare the effects of 20 IU oxytocin infusion and 5 IU bolus with 5 IU bolus and 500ml normal saline on the control of blood loss in ante-partum lower segment caesarean section.Methods A double-blind randomized controlled trial was conducted in the Teaching Hospital, Peradeniya, Sri Lanka. Ninety two pregnant women, forty six from each group were randomized to receive either intravenous slow 5 IU oxytocin bolus over 1 minute and additional 20 IU oxytocin infusion in 500 ml of 0.9% saline solution over 4 hours (Group-A) or 5 IU oxytocin bolus over 1 minute and 500 ml of 0.9% Saline over 4 hours (Group B). Visual assessment of mean blood loss was done by the surgeon and anaesthetist. Blood loss was calculated based on the body weight and haematocrit before and 48 hours after delivery. Other outcome measures were mean blood loss, major obstetric haemorrhage (>1000 ml), need of additional uterotonics and blood transfusions. Results Calculated mean blood loss (456.0ml vs 569.8ml) was significantly less in group A (p=0.046). Visual estimation of blood loss by surgeon (476.9 vs 552.1) (p=0.01) and anaesthetist? (492.7 vs 557.2) (p= 0.03) were also significantly less in group A. Conclusion Additional oxytocin infusion at ante-partum caesarean section reduces blood loss during and after caesarean section significantly.
机译：简介产科出血是全球孕产妇死亡的主要原因，在大多数情况下，它与子宫收缩乏力有关。即使常规使用催产素推注，如果发生出血，也可能需要额外输注催产素。目的比较20 IU催产素，5 IU大剂量推注，5 IU大剂量推注和500ml生理盐水对产前下节剖腹产术失血的控制效果。方法在教学中进行了双盲随机对照试验斯里兰卡佩拉德尼亚医院。九十二名孕妇（每组四十六名）被随机分配在1分钟内接受静脉缓慢的5 IU催产素推注，并在4小时内（A组）在500 ml的0.9％盐溶液中额外注入20 IU催产素（A组）或5 IU催产素在1分钟内推注一次，然后在4小时内注入500毫升0.9％的盐水（B组）。目视评估平均失血量由外科医生和麻醉师进行。根据分娩前和分娩后48小时的体重和血细胞比容计算失血量。其他预后指标包括平均失血量，严重的产科出血（> 1000 ml），是否需要额外的子宫内注射和输血。结果A组的平均失血量（456.0ml对569.8ml）显着减少（p = 0.046）。由外科医生（476.9 vs 552.1）（麻醉师）和麻醉师目视评估失血量（p = 0.01）？ A组也分别显着减少（492.7 vs 557.2）（p = 0.03）。结论剖腹产前和剖腹产后追加催产素输注可显着减少失血。

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