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首页> 外文期刊>Cardiovascular Journal >Prognostic Value of NT-proBNP in Predicting Adverse In-hospital Outcomes among Patients of STEMI getting Thrombolytic therapy without Clinical Manifestation of Heart Failure
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Prognostic Value of NT-proBNP in Predicting Adverse In-hospital Outcomes among Patients of STEMI getting Thrombolytic therapy without Clinical Manifestation of Heart Failure

机译:NT-proBNP在预测溶栓治疗而无心衰临床表现的STEMI患者中院内不良预后的预后价值

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Background: Risk stratification is extremely important in ACS patients especially acute STEMI. We studied in-hospital outcomes of acute STEMI according to their NT-proBNP level as a new prognostic marker.Methods: This observational prospective study was conducted to evaluate the significance of raised plasma NT-proBNP level on in-hospital outcomes in patients with STEMI, without clinical manifestation of heart failure. A total 88 patients of STEMI were included in the study. Among them 10 Patients have normal levels of NT-proBNP (<110 pg/ml) and were included in Group-A (n = 10). Patients with increased proBNP level (e”110 pg/ml) were included in Group-B (n = 78). Patients were followed to see worse in-hospital outcomes (Heart failure, cardiogenic shock, significant arrhythmia and death) during index hospitalization period.Results: Plasma NT-proBNP level was observed to be significantly higher among patients who developed heart failure, cardiogenic shock and death than the patients who did not developed these outcome (p < 0.001). The binary logistic regression analysis of Odds Ratios for characteristics of the patients likely to cause worse in-hospital outcome shows that NT-ProBNP and smoking habit were found to be the independent predictors of worse in-hospital outcome with ORs being 5.0 and 4.7 respectively.Conclusion: On admission plasma NT-pro BNP level in patients with STEMI is a strong independent predictor of adverse in-hospital outcome.Cardiovasc. j. 2017; 10(1): 8-12
机译:背景:风险分层对于ACS患者尤其是急性STEMI患者极为重要。我们根据其NT-proBNP水平作为新的预后标志物研究了急性STEMI的院内预后。方法:这项观察性前瞻性研究旨在评估血浆NT-proBNP水平升高对STEMI患者的院内预后的意义。 ,无心力衰竭的临床表现。该研究共纳入88名STEMI患者。其中10例患者的NT-proBNP水平正常(<110 pg / ml),被纳入A组(n = 10)。 proBNP水平升高(e” 110 pg / ml)的患者被纳入B组(n = 78)。结果:在发生心力衰竭,心源性休克和心律失常的患者中,血浆NT-proBNP水平显着升高,患者在住院期间的院内预后较差(心力衰竭,心源性休克,明显的心律失常和死亡)。死亡的患者比未取得这些预后的患者高(p <0.001)。可能导致住院结局恶化的患者特征的比值比值的二进制logistic回归分析表明,NT-ProBNP和吸烟习惯是院内结局恶化的独立预测因子,OR分别为5.0和4.7。结论:STEMI患者入院时血浆NT-pro BNP水平是院内不良预后的有力独立预测指标。 j。 2017; 10(1):8-12

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