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首页> 外文期刊>Cases Journal >Dexamethasone-induced flares of Trichophyton rubrum masquerading as docetaxel cutaneous toxicity: a case report
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Dexamethasone-induced flares of Trichophyton rubrum masquerading as docetaxel cutaneous toxicity: a case report

机译：地塞米松诱导的红毛癣菌耀斑伪装成多西他赛皮肤毒性：一例

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摘要

Docetaxel chemotherapy is increasingly used in the treatment of castration-resistant prostate cancer. Cutaneous toxicity is common with docetaxel, occurring in up to 75% of cases. We present an unusual case of castration-resistant prostate cancer in which our patient developed recurrent but transient episodes of skin rash following each cycle of docetaxel. Initially, the rash was attributed to docetaxel cutaneous toxicity however a microbiological diagnosis of Trichophyton rubrum was subsequently made. We postulated that dexamethasone pre-medication transiently suppressed anti-fungal immunity, and indeed further flares were prevented by significantly reducing the dose of dexamethasone while continuing treatment with docetaxel.
机译：多西他赛化疗越来越多地用于治疗去势抵抗性前列腺癌。多西紫杉醇的皮肤毒性很常见，高达75％的病例发生。我们介绍了一个罕见的去势抵抗性前列腺癌病例，在该病例中，多西他赛的每个周期后，患者出现皮疹复发但短暂发作。最初，皮疹归因于多西紫杉醇的皮肤毒性，但随后进行了微生物学诊断为毛癣菌。我们推测地塞米松的服药前短暂抑制了抗真菌免疫力，实际上通过在继续用多西紫杉醇治疗的同时显着减少地塞米松的剂量可以预防进一步的发作。

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