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首页> 外文期刊>Cases Journal >Life-threatening hyponatremia due to intravenous n-acetylcysteine treatment in an infant: a case report
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Life-threatening hyponatremia due to intravenous n-acetylcysteine treatment in an infant: a case report

机译：静脉内n-乙酰半胱氨酸静脉注射治疗可危及生命的低钠血症：一例报告

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Introduction N-acetylcysteine has proven to be effective in paracetamol intoxications, but there is no consensus regarding its way of administration. Here, we report a case to highlight the importance of careful management of intravenous n-acetylcysteine. Case presentation A two-month old infant was seen in our paediatric emergency department due to paracetamol poisoning after repeated supratherapeutic doses. She was treated with intravenous n-acetylcysteine diluted with dextrose 5%, according to the 20-hour standard protocol. Eight hours later she developed two tonic-clonic seizures and was subsequently intubated. By that time, she had received almost 1 liter of 5% dextrose, and serum sodium was 114 mg/dL. A rapid correction was done with hypertonic saline and the child experienced a good outcome, without any sequelae. Conclusion Intravenous n-acetylcysteine administration must be done carefully. Amount of liquid administrated and sodium monitoring should be kept in mind, with special care in small children.
机译：引言N-乙酰半胱氨酸已被证明可有效抑制扑热息痛中毒，但尚无共识。在这里，我们报告一例病例，以突出说明静脉内n-乙酰半胱氨酸的谨慎管理的重要性。病例介绍反复超剂量治疗后，由于对乙酰氨基酚中毒，在我们的儿科急诊室发现了一个两个月大的婴儿。根据20小时标准方案，用静脉内用5％葡萄糖稀释的n-乙酰半胱氨酸进行治疗。八小时后，她出现了两次强直性阵挛性癫痫发作，随后被插管。到那时，她已经接受了将近1升的5％葡萄糖，血清钠为114 mg / dL。用高渗盐水进行了快速矫正，孩子的预后良好，没有后遗症。结论静脉注射n-乙酰半胱氨酸必须谨慎。应牢记服用液体的量和钠的监测，并在幼儿中要特别注意。

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