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首页> 外文期刊>Cases Journal >The first case of isolated facial cutanenous leishmaniasis in a Down syndrome infant: a case report and review of the literature
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The first case of isolated facial cutanenous leishmaniasis in a Down syndrome infant: a case report and review of the literature

机译：唐氏综合症婴儿中的第一例孤立的面部皮肤利什曼病：一例病例报告并文献复习

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Background Cutaneous leishmaniasis can be caused by several Leishmania species and is transmitted to human beings and animals by sand flies, Down syndrome is known to cause immunodeficiency that might lead to increase the susceptibility to infection with Leishmania. Up to our knowledge this is the first case of isolated facial cutaneous leshmaniasis in association with Down syndrome. Case presentation A 2 month old Saudi Arabian male infant was admitted in the pediatric ward of maternity and children's hospital, Buraidah, Kingdom of Saudi Arabia for the management of multiple ulcers on his face, two ulcers were big and were surrounded by edema, causing severe disfigurement. This disfigurement caused difficulty in recognizing the facial feature of Down syndrome. The presence of hypotonia, microcephaly, low set ears, bilateral simian creases and wide separation between big toe and other toes directed us to request karyotyping. The result of karyotyping confirmed the diagnosis of Down syndrome. Conclusion Children with Down syndrome are immunodeficient, they have been reported to have a complex of immunological alterations which might lead to increased susceptibility to infection.
机译：背景技术皮肤利什曼病可以由几种利什曼原虫物种引起，并通过沙蝇传播给人类和动物。唐氏综合症已知会引起免疫缺陷，可能导致增加对利什曼原虫感染的易感性。据我们所知，这是首例与唐氏综合症相关的面部皮肤去皮病。病例介绍一名2个月大的沙特阿拉伯男婴因治疗面部多发性溃疡而被送进沙特阿拉伯王国布赖达妇产科和儿科医院的儿科病房，其中两个溃疡较大，周围有水肿，导致重度溃疡。毁容。这种毁容性导致难以识别唐氏综合症的面部特征。肌张力低下，小头畸形，耳朵偏低，双侧猿猴折痕以及大脚趾和其他脚趾之间的距离较大，这导致我们要求进行核型分析。核型分析的结果证实了唐氏综合症的诊断。结论唐氏综合症患儿免疫缺陷，据报道他们的免疫学改变复杂，可能导致感染的易感性增加。

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