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首页> 外文期刊>Cases Journal >Bilateral Brown syndrome in one pair of dizygotic twins: a case report
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Bilateral Brown syndrome in one pair of dizygotic twins: a case report

机译：一对同卵双胞胎的双侧布朗综合征：一例报告

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Introduction Brown syndrome is a rare ocular movement abnormality. This syndrome is characterized by an inability to elevate the affected eye in adduction. Most cases are sporadic but the occurrence in Monozygotic twins has suggested the possible autosomal dominant inheritance in Brown syndrome. Case presentation A 4-year-old girl (one pair of dizygotic twins) was referred to our pediatric ophthalmology clinic to assess her abnormal eye movement noticed by her mother. Visual acuity of both eyes was 20/20 with Snellen chart. Ocular motility showed mild exotropia in primary position with marked divergence in upward gaze (V pattern), mild hypotropia in adduction, and limitation of elevation in adduction of both eyes (Fig. 1A ). We also examined her sister, all ocular evaluations including visual acuity, slit lamp examination, funduscopy and ocular motility (Ductions & Versions) were normal without any limitation. We also review the related articles that previously have reported Brown syndrome in twins. Conclusion Although there are few case reports of Brown syndrome in twins, combination of these reports may elucidate the genetic basis of this disease.
机译：简介布朗综合征是一种罕见的眼球运动异常。该综合征的特征在于不能升高患眼内收。大多数病例是零星的，但在单卵双胞胎中的发生表明布朗综合征可能是常染色体显性遗传。病例介绍一名4岁女孩（一对同卵双胞胎）被转送到我们的儿科眼科诊所，以评估母亲发现的异常眼球运动。用Snellen图，两只眼睛的视力为20/20。眼球运动的主要部位表现为轻度外斜视，向上凝视明显发散（V型），内收轻度眼斜视，双眼内收眼抬高受限（图1A）。我们还检查了她的姐姐，所有视力评估（包括视敏度，裂隙灯检查，眼底镜检查和眼部运动）（抽吸和版本）均正常，无任何限制。我们还回顾了以前报道双胞胎布朗综合征的相关文章。结论尽管双胞胎中没有布朗综合征的病例报道，但这些报道的结合可以阐明这种疾病的遗传基础。

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