• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Channels >Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance
【24h】

Role of volume-regulated and calcium-activated anion channels in cell volume homeostasis, cancer and drug resistance

机译：体积调节和钙激活的阴离子通道在细胞体积稳态，癌症和耐药性中的作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Volume-regulated channels for anions (VRAC) / organic osmolytes (VSOAC) play essential roles in cell volume regulation and other cellular functions, e.g. proliferation, cell migration and apoptosis. LRRC8A, which belongs to the leucine rich-repeat containing protein family, was recently shown to be an essential component of both VRAC and VSOAC. Reduced VRAC and VSOAC activities are seen in drug resistant cancer cells. ANO1 is a calcium-activated chloride channel expressed on the plasma membrane of e.g., secretory epithelia. ANO1 is amplified and highly expressed in a large number of carcinomas. The gene, encoding for ANO1, maps to a region on chromosome 11 (11q13) that is frequently amplified in cancer cells. Knockdown of ANO1 impairs cell proliferation and cell migration in several cancer cells. Below we summarize the basic biophysical properties of VRAC, VSOAC and ANO1 and their most important cellular functions as well as their role in cancer and drug resistance.
机译：阴离子（VRAC）/有机渗透物（VSOAC）的体积调节通道在细胞体积调节和其他细胞功能中起重要作用，例如增殖，细胞迁移和凋亡。 LRRC8A属于含亮氨酸重复序列丰富的蛋白质家族，最近被证明是VRAC和VSOAC的重要组成部分。在耐药性癌细胞中发现VRAC和VSOAC活性降低。 ANO1是在例如分泌性上皮的质膜上表达的钙激活的氯离子通道。 ANO1在许多癌中被扩增并高度表达。编码ANO1的基因定位到11号染色体（11q13）上经常在癌细胞中扩增的区域。敲低ANO1会损害几种癌细胞的细胞增殖和细胞迁移。下面我们概述了VRAC，VSOAC和ANO1的基本生物物理特性，以及它们最重要的细胞功能以及它们在癌症和耐药性中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号