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Molecular sensors and modulators of thermoreception

机译：分子传感器和热受体调节剂

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摘要

The detection of temperature is one of the most fundamental sensory functions across all species, and is critical for animal survival. Animals have thus evolved a diversity of thermosensory mechanisms allowing them to sense and respond to temperature changes (thermoreception). A key process underlying thermoreception is the translation of thermal energy into electrical signals, a process mediated by thermal sensors (thermoreceptors) that are sensitive to a specific range of temperatures. In disease conditions, the temperature sensitivity of thermoreceptors is altered, leading to abnormal temperature sensation such as heat hyperalgesia. Therefore, the identification of thermal sensors and understanding their functions and regulation hold great potential for developing novel therapeutics against many medical conditions such as pain.
机译：温度的检测是所有物种最基本的感觉功能之一，对于动物的生存至关重要。因此，动物进化出了多种热感觉机制，使它们能够感知并响应温度变化（热感受）。热接收的关键过程是将热能转换为电信号，这是由对特定温度范围敏感的热传感器（热敏电阻）介导的过程。在疾病条件下，热感受器的温度敏感性会发生变化，从而导致异常的温度感觉，例如热痛觉过敏。因此，识别热传感器并理解其功能和调节对于开发针对许多医学状况（例如疼痛）的新型疗法具有巨大的潜力。

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