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首页> 外文期刊>Chemical and Pharmaceutical Bulletin >Development and Characterization of Oral Spray for Stomatitis Containing Irsogladine Maleate
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Development and Characterization of Oral Spray for Stomatitis Containing Irsogladine Maleate

机译：马来酸伊索拉定口腔喷雾剂的研制与表征

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The stomatitis caused by anticancer agents and radiation therapy deteriorates patient QOL, potentially causing eating disorders as a result of pain. Although gargling and ointments can be used in the treatment of stomatitis, patients must spit out mouthwash after use, while ointment application requires a finger to be inserted into the oral cavity. In contrast, sprays eliminate these potential compliance problems. Therefore, we developed a stomatitis spray that remains on the oral mucosa. It has been reported that irsogladine maleate (IM) is effective against stomatitis via oral administration. IM is water insoluble; thus, it was dissolved with various cyclodextrins (CDs). Furthermore, we examined combination with gum ghatti (GG), a mucoadhesive polymer. The interaction between mucin and GG was examined by Quartz Crystal Microbalance with Dissipation monitoring. We found that GG exhibited mucoadhesion. Furthermore, we examined the healing effects of IM on stomatitis in a stomatitis model hamster. We found that stomatitis healed after direct application of IM. However, the model used in this experiment is not based on stomatitis caused by anticancer agents. Further study is therefore necessary.
机译：由抗癌药和放射疗法引起的口腔炎会使患者的生活质量恶化，并可能由于疼痛而导致进食障碍。尽管漱口剂和药膏可用于治疗口腔炎，但患者在使用后必须吐出漱口水，而药膏的应用则需要将手指插入口腔。相反，喷雾消除了这些潜在的合规性问题。因此，我们开发了残留在口腔粘膜上的口腔炎喷雾剂。据报道，马来酸伊索拉定（IM）可通过口服有效地对抗口腔炎。 IM不溶于水;因此，它被各种环糊精（CD）溶解。此外，我们检查了与粘膜胶粘剂聚合物ghatti（GG）的组合。通过具有耗散监测的石英晶体微量天平检测粘蛋白与GG之间的相互作用。我们发现GG表现出粘膜粘附。此外，我们在口炎模型仓鼠中检查了IM对口炎的愈合效果。我们发现直接应用IM后口腔炎已he愈。但是，此实验中使用的模型并非基于抗癌药引起的口腔炎。因此，有必要进一步研究。

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