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首页> 外文期刊>Case Reports in Infectious Diseases >First Description of KPC-2-ProducingKlebsiella oxytocaIsolated from a Pediatric Patient with Nosocomial Pneumonia in Venezuela
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First Description of KPC-2-ProducingKlebsiella oxytocaIsolated from a Pediatric Patient with Nosocomial Pneumonia in Venezuela

机译：委内瑞拉一名小儿医院肺炎患者的产KPC-2产产克雷伯菌的首次描述

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During the last decade, carbapenem resistance has emerged among clinical isolates of the Enterobacteriaceae family. This has been increasingly attributed to the production ofβ-lactamases capable of hydrolyzing carbapenems. Among these enzymes,Klebsiella pneumoniaecarbapenemases (KPCs) are the most frequently and clinically significant class-A carbapenemases. In this report, we describe the first nosocomial KPC-2-producingK. oxytocaisolated from a pediatric patient with pneumonia admitted to the intensive care unit at The Andes University Hospital, Mérida, Venezuela. This strain was resistant to several antibiotics including imipenem, ertapenem, and meropenem but remained susceptible to ciprofloxacin, colistin, and tigecycline. Conjugation assays demonstrated the transferability of all resistance determinants, except aminoglycosides. The isolate LMM-SA26 carried a ~21 kb conjugative plasmid that harbored theblaKPC-2,blaCTX-M-8, andblaTEM-15genes. Although carbapenem resistance in the Enterobacteriaceae is still unusual in Venezuela, KPCs have a great potential to spread due to their localization on mobile genetic elements. Therefore, rapid detection of KPC-carrying bacteria with phenotypic and confirmatory molecular tests is essential to establish therapeutic options and effective control measures.
机译：在过去的十年中，对碳青霉烯类药物的耐药性已经出现在肠杆菌科的临床分离株中。这已经越来越多地归因于能够水解碳青霉烯的β-内酰胺酶的生产。在这些酶中，肺炎克雷伯菌（Klebsiella pneumoniaecarbapenemases）（KPC）是最常见且临床意义上的A类碳青霉烯酶。在此报告中，我们描述了第一个医院KPC-2生产型K。来自委内瑞拉梅里达安第斯大学医院重症监护病房的小儿肺炎患者的催产素分离。该菌株对包括亚胺培南，厄他培南和美洛培南在内的几种抗生素具有抗性，但仍对环丙沙星，粘菌素和替加环素敏感。偶联测定证明了除氨基糖苷以外的所有抗性决定簇的转移能力。分离的LMM-SA26携带〜21个kb的结合质粒，该质粒带有blaKPC-2，blaCTX-M-8和blaTEM-15基因。尽管委内瑞拉肠杆菌科对碳青霉烯类药物的耐药性在委内瑞拉仍然不常见，但由于KPCs位于移动遗传元件上，因此具有很大的传播潜力。因此，通过表型和验证性分子测试快速检测携带KPC的细菌对于建立治疗选择和有效控制措施至关重要。

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