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首页> 外文期刊>Case Reports in Gastroenterology >Calcium Channel Blockers and Esophageal Sclerosis: Should We Expect Exacerbation of Interstitial Lung Disease
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Calcium Channel Blockers and Esophageal Sclerosis: Should We Expect Exacerbation of Interstitial Lung Disease

机译：钙通道阻滞剂和食管硬化症：我们应该预期间质性肺疾病的恶化吗

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摘要

Esophageal sclerosis is the most common visceral manifestation of systemic sclerosis, resulting in impaired esophageal clearance and retention of ingested food; in addition, co-existence of lung fibrosis with esophageal scleroderma is not uncommon. Both the progression of generalized connective tissue disorders and the damaging effect of chronic aspiration due to esophageal dysmotility appear to be involved in this procedure of interstitial fibrosis. Nifedipine is a widely prescribed calcium antagonist in a significant percentage of rheumatologic patients suffering from Raynaud syndrome, in order to inhibit peripheral vasospasm. Nevertheless, blocking calcium channels has proven to contribute to exacerbation of gastroesophageal reflux, which consequently can lead to chronic aspiration. We describe the case of severe exacerbation of interstitial lung disease in a 76-year-old female with esophageal sclerosis who was treated with oral nifedipine for Raynaud syndrome.
机译：食管硬化症是全身性硬化症最常见的内脏表现，导致食道清除功能受损和摄入食物滞留;此外，肺纤维化与食道硬皮病并存并不罕见。广泛的结缔组织疾病的进展和由于食管运动障碍引起的慢性误吸的破坏作用似乎都参与了这种间质纤维化过程。硝苯地平是广泛使用的钙拮抗剂，可用于抑制雷诺德综合症的风湿病患者中，以抑制周围血管痉挛。然而，事实证明，阻塞钙通道会加剧胃食管反流，进而导致慢性误吸。我们描述了一名患有食管硬化症的76岁女性患者的间质性肺疾病严重加重的病例，该患者接受口服硝苯地平治疗雷诺综合征。

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