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Visceral Hyperalgesia: When to Consider Gabapentin Use in Neonatesa??Case Study and Review

机译:内脏痛觉过敏:何时在新生儿中考虑使用加巴喷丁?

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Visceral hyperalgesia refers to increased pain sensation in response to gastrointestinal sensory stimulus. In neonates with neurological impairments, gabapentin has been successfully used as a treatment for visceral hyperalgesia in neonates. The authors describe a preterm infant with myelomeningocele and persistent neuropathic pain that manifested as irritability, hypertonicity, poor weight gain, and feeding intolerance. After exclusion of other etiologies, the diagnosis of visceral hyperalgesia was suspected and the infant was treated with gabapentin. Following appropriate titration to effect and close monitoring of side effects of gabapentin, he subsequently demonstrated improved tone, decreased irritability with feedings, and appropriate weight gain. In addition, the authors provide a review of the available literature of gabapentin use in neonates and offer suggestions on when to consider starting gabapentin in a neonate with neurological impairment and chronic unexplained gastrointestinal manifestations.
机译:内脏痛觉过敏是指响应胃肠道感觉刺激而增加的疼痛感。在神经功能缺损的新生儿中,加巴喷丁已成功用于治疗内脏痛觉过敏。作者描述了早产儿患有脊髓膜脑膜膨出和持续的神经性疼痛,表现为烦躁不安,高渗,体重增加不佳和喂养不耐受。排除其他病因后,怀疑可诊断为内脏痛觉过敏,并对该婴儿进行了加巴喷丁治疗。在适当滴定效果并密切监测加巴喷丁的副作用后,他随后表现出语气改善,进食时烦躁不安和体重增加。此外,作者对加巴喷丁在新生儿中的可用文献进行了综述,并提供了有关何时考虑在神经功能障碍和慢性胃肠道疾病无法解释的新生儿中开始加巴喷丁的建议。

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