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首页> 外文期刊>Chemical Science International Journal >A Review on Synthesis and Spectral Properties ofQuinazolines and Pyrimidines
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A Review on Synthesis and Spectral Properties ofQuinazolines and Pyrimidines

机译：喹唑啉和嘧啶的合成及光谱性质研究进展

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Heterocyclic compounds has become a significant role in human life due to the different uses of these compounds. This type of compounds found strong attention among chemists and interested by studying the methods of their synthesis and study their properties. Heterocyclic compounds used in different fields like medicine, pharmacy, agriculture and industry and widely credited for development of human life. Study of these compounds occupies a prominent place in the science of chemistry. Heterocyclic compounds as known it is contain two different types of atoms in their structure so it was great interest in the synthesis and study their chemical, physical characteristics and spectral characteristics. Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, heterocyclic structures form the basis of many pharmaceutical, agrochemical and veterinary products. Heterocycles make up an exceedingly important class of compounds. In fact more than half of all known organic compounds are heterocycles. Many natural drugs such as quinine, palavering, emetine, theophylline, atropine, procaine, codeine, morphine and reserving are heterocycles. Almost all the compounds we know as synthetic drugs such as diazepam, chlorpromazine, ionized, metronidazole, azidothymidine, barbiturates, antipyrine, captopril and methotrexate are also heterocycles. Some dyes, luminophores, pesticides and herbicides are also heterocyclic in nature. One of the main objectives of organic and medicinal chemistry is the design, synthesis and production of molecules having value as human therapeutic agents. There are numerous biologically active molecules with six-membered rings, containing two hetero atoms. The development of research on biological activity of quinazoline compounds started when the compound 2-methyl-1, 3-aryl-4-quinazoline derivative was synthesized. This compound has soporific and sedative action. Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms at positions 1 and 3 of the six-member ring. pyrimidine has many properties in common with pyridine, as the number of nitrogen atoms in the ring increases the ring pi electrons become less energetic and electrophilic aromatic substitution gets more difficult while nucleophilic aromatic substitution gets easier. In this report has been explained different methods synthesis of these compounds and study their spectral properties. I hope to benefit chemists and who interested in studying this type of compounds.? Retraction Notice: This paper has been retracted from the journal after receipt of written complains. This journal is determined to promote integrity in research publication. This retraction is in spirit of the same. After formal procedures editor(s) and publisher have retracted this paper on 13~(th) April-2017.
机译：由于这些化合物的不同用途，杂环化合物已成为人类生活中的重要角色。这类化合物在化学家中引起了广泛关注，并通过研究其合成方法和性质对其感兴趣。杂环化合物用于医学，制药，农业和工业等不同领域，被广泛认为是人类生活的发展。这些化合物的研究在化学科学中占有重要地位。众所周知，杂环化合物在其结构中包含两种不同类型的原子，因此在合成和研究其化学，物理特性和光谱特性方面引起了极大兴趣。杂环化学至少占全球所有有机化学研究的一半。杂环结构尤其是许多药物，农用化学品和兽医产品的基础。杂环构成极其重要的一类化合物。实际上，所有已知有机化合物中有一半以上是杂环。许多天然药物，例如奎宁，帕拉维宁，盐酸美西汀，茶碱，阿托品，普鲁卡因，可待因，吗啡和保留剂都是杂环。我们所知道的几乎所有作为合成药物的化合物，例如地西epa，氯丙嗪，离子化，甲硝唑，叠氮胸苷，巴比妥酸盐，安替比林，卡托普利和甲氨蝶呤也是杂环。一些染料，发光体，杀虫剂和除草剂在性质上也是杂环的。有机和药物化学的主要目标之一是设计，合成和生产具有人类治疗剂价值的分子。有许多具有六元环的生物活性分子，其中含有两个杂原子。当合成化合物2-甲基-1，3-芳基-4-喹唑啉衍生物时，就开始了对喹唑啉化合物生物活性的研究。该化合物具有镇静和镇静作用。嘧啶是类似于苯和吡啶的杂环芳族有机化合物，在六元环的1和3位含有两个氮原子。嘧啶具有与吡啶相同的许多特性，因为环中的氮原子数增加，环pi电子的能量降低，亲电子芳族取代变得更加困难，而亲核芳族取代变得更加容易。在本报告中，已解释了这些化合物的不同合成方法并研究了它们的光谱特性。我希望对化学家以及对研究此类化合物感兴趣的化学家们受益。撤回通知：收到书面投诉后，该文件已从日记本中撤回。该期刊旨在促进研究出版物的完整性。这种退缩是本着相同的精神。经过正式程序后，编辑和出版商已于2017年4月13日至13日撤回本文。

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