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首页> 外文期刊>Chemical Sciences Journal >Design-Syntheses, Characterization and Biological Activity Studies of Azobenzen-P,P?a????-Di(3,1-Benzoxazin-4-One-2yl) and Azobenzen-P,P?a????-Di[(3- Substituted 3(4H)Quinazolinone-2yl] Derivatives
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Design-Syntheses, Characterization and Biological Activity Studies of Azobenzen-P,P?a????-Di(3,1-Benzoxazin-4-One-2yl) and Azobenzen-P,P?a????-Di[(3- Substituted 3(4H)Quinazolinone-2yl] Derivatives

机译：Azobenzen-P，P？a ????-Di（3,1-Benzoxazin-4-One-2yl）和Azobenzen-P，P？a ??????-Di的设计合成，表征和生物活性研究[（3-取代3（4H）喹唑啉酮-2yl]衍生物

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Sixteen azobenzene-p,pê??-di[3-substituted-4(3H)quinazolinone-2yl] were synthesized from reaction of azobenzenp, pê??-di(3,1-benzoaxzin-4-one-2yl) with amino-moieties nucleophlies, like hydrazinehydrate, hydroxylamine, p,toluidine, p-aminobenzene sulphonamide, 2-pyrimidine, 5-nitro-2-aminopyridine, ethyleneamine,5-(p-bromo) phenyl-2-aminothiazol, p,pê??-diamino diphenyl sulphone, quinidine hydrochloride, urea, thiourea, 3,5-dimethyl- 2-phenyl-4-aminopyrazolin-3-one, N(5-methyl-3-isoxazolyl)-p-aminobenzen sulphonamide, semicarbazide and thiosemicarbazide, in a molar ratio (1:2) respectively. azobenzen-p,pê??-di(3,1-benzoaxzin-4-one-2yl), was synthesized by following serial synthetic pathway. Reductive-condensation of p-nitrobenzoic acid in basic media give azobenzenp, pê??-dicarboxylic acid, then treated with thionyl chloride to give azobenzen-p,pê??-diacid chloride. It condensed with anthranilic acid to give azobenzen-p,pê??-[(dibenzoic acid-2yl)dicarboxamide], upon treatment with thionyl chloride give azobenzen-p,pê??-di(3,1-benzoaxzin-4-one-2yl). All synthesized compounds characterized by FTIR, 1HNMR, 13CNMR and mass spectral analyses. All synthesized azobenzen-p,pê??-di(3,1-benzoaxzin-4-one-2yl), and sixteen azobenzenep, pê??-di[3-substituted-4(3H)quinazolinone-2yl] compounds, were examined as antibacterial agents against gm(+ve and –ve) bacteria, and antifungal agents. Results showed abroad extended to moderate effects as antibacterial and antifungal agents.
机译：由偶氮苯zen，pêβ-二（3,1-苯并恶嗪-4-one-2yl）与氨基反应合成了十六个偶氮苯-p，pêβ-二[3-取代-4（3H）喹唑啉酮-2基] -部分核苷酸，如水合肼，羟胺，对甲苯胺，对氨基苯磺酰胺，2-嘧啶，5-硝基-2-氨基吡啶，亚乙基胺，5-（对溴）苯基-2-氨基噻唑，对氨基苯甲酸-二氨基二苯砜，盐酸奎尼丁，尿素，硫脲，3,5-二甲基-2-苯基-4-氨基吡唑啉-3-酮，N（5-甲基-3-异恶唑基）-对氨基苯磺酰胺，氨基脲和硫代氨基脲，分别以1：2的摩尔比。偶氮苯-p，pê-β-二（3,1-苯并恶嗪-4-one-2yl），是通过以下系列合成途径合成的。对-硝基苯甲酸在碱性介质中的还原缩合反应得到偶氮苯p，pêα-二羧酸，然后用亚硫酰氯处理得到偶氮苯zen-p，pêα-二酰氯。它与邻氨基苯甲酸缩合得到偶氮苯-p，pê??-[（（二苯甲酸-2基）二甲酰胺]，用亚硫酰氯处理后得到偶氮苯-p，pê??-二（3,1-苯并恶嗪-4-一-2yl）。所有合成的化合物都具有FTIR，1HNMR，13CNMR和质谱分析的特征。所有合成的偶氮苯-p，pêβ-二（3,1-苯并恶嗪-4-one-2yl）和十六个偶氮苯p，βε-二[3-取代-4（3H）喹唑啉酮-2基]化合物作为抗gm（+ ve和–ve）细菌的抗菌剂和抗真菌剂进行了测试。结果表明，在国外，抗菌和抗真菌剂的作用已扩大到中等程度。

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