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首页> 外文期刊>CHROMATOGRAPHY >Nicotine-Selective Polymeric Adsorbent Obtained by Molecular Imprinting with Excess Use of Itaconic Acid
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Nicotine-Selective Polymeric Adsorbent Obtained by Molecular Imprinting with Excess Use of Itaconic Acid

机译：通过衣康酸的分子印迹获得尼古丁选择性聚合物吸附剂

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Currently, nicotine is mostly analyzed by chromatography with pretreatment such as solid phase extraction (SPE). One of effective pretreatment techniques would be affinity extraction; however, there is no practical biomolecular affinity media available for SPE of nicotine. Molecular imprinting has been studied as a methodology for producing nicotine-selective synthetic affinity media, which relies on the formation of complex species between a target molecule (as template) and functional monomer; therefore, the selection of functional monomer is greatly important for obtaining molecularly imprinted polymers (MIPs) with high affinity and selectivity. In this study, itaconic acid (IA), which bears two carboxyl groups, was used as functional monomer in the synthesis of nicotine selective-MIPs. Other acidic monomers, such as methacrylic acid (MA), 2-(trifluoromethyl)acrylic acid (FM) and methyl itaconate (MI) were compared with IA to evaluate their usefulness as functional monomer. In chromatographic tests, the retention factor for nicotine on a MIP synthesized with itaconic acid (IP-IA16) was 40.4, which was 3.1 times that on a non-imprinted polymer (BP-IA16), while the retention factor on MIPs with the other monomers was 21.6 or less and was 1.1 times that on corresponding non-imprint blank polymers (BPs). In the selectivity test using cotinine, 3-methylpyridine and N -methylpyrrolidine as reference compounds, IP-IA16 showed the largest retention factor for nicotine, which was more than 4.4 times that of the other compounds, suggesting that nicotine-recognition sites were formed in MIPs by the molecular imprinting using IA as functional monomer.
机译：目前，尼古丁主要通过色谱法进行预处理，例如固相萃取（SPE）。一种有效的预处理技术是亲和提取。然而，目前尚无实用的生物分子亲和介质可用于尼古丁的SPE。已经研究了分子印迹作为生产尼古丁选择性合成亲和介质的方法，该介质依赖于目标分子（作为模板）与功能单体之间形成复杂的物种。因此，功能单体的选择对于获得具有高亲和力和选择性的分子印迹聚合物（MIP）至关重要。在这项研究中，带有两个羧基的衣康酸（IA）被用作合成尼古丁选择性MIP的功能单体。将其他酸性单体，例如甲基丙烯酸（MA），2-（三氟甲基）丙烯酸（FM）和衣康酸甲酯（MI）与IA进行比较，以评估它们作为功能单体的用途。在色谱测试中，衣康酸合成的MIP（IP-IA16）上尼古丁的保留因子是40.4，是非印迹聚合物（BP-IA16）的3.1倍，而MIPs上其他成分的保留因子单体为21.6或更小，是相应非印迹空白聚合物（BP）的1.1倍。在使用可替宁，3-甲基吡啶和N-甲基吡咯烷作为参比化合物的选择性试验中，IP-IA16显示出最大的尼古丁保留因子，是其他化合物的4.4倍以上，这表明尼古丁识别位点通过使用IA作为功能单体的分子印迹在MIP中形成分子。

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