摘要:为准确测定电子烟气溶胶中关键成分(1,2-丙二醇、丙三醇和烟碱)的释放量,了解工作电压对其释放量的影响,通过考察内标、萃取剂体积以及萃取时间等因素,建立了检测电子烟气溶胶中1,2-丙二醇、丙三醇和烟碱释放量的气相色谱方法,并在不同工作电压下对3种烟液(烟油)进行了测定.结果表明:①方法灵敏度高、重复性好、回收率高,适用于电子烟气溶胶中1,2-丙二醇、丙三醇和烟碱的定量分析.②在3.7~6.9 V范围内,随着工作电压的升高,气溶胶中的TPM、1,2-丙二醇、丙三醇和烟碱的释放量均增加,其中TPM释放量与工作电压线性相关(R2≥0.9806).③烟油中烟碱浓度与气溶胶中烟碱释放量正相关;气溶胶中烟碱与1,2-丙二醇之间的相关性最强(R2≥0.9918),表明1,2-丙二醇对烟碱递送起关键作用.④方差分析表明工作电压和烟油中烟碱浓度均对气溶胶中烟碱释放量有显著影响,偏η2值比较表明烟油中烟碱浓度的影响程度略大于工作电压.%In order to accurately determine the release of key components (1,2-propylene glycol, glycerol and nicotine) in the aerosol of e-cigarettes and to investigate the influence of device voltage on the release, a gas chromatography method for the determination of 1,2-propylene glycol, glycerol and nicotine contents in the aerosol of e-cigarette was developed. A number of factors were investigated, such as internal standards, extraction solvent volume, extraction time, etc. Based on the developed method, three e-liquids were analyzed under different voltages. The results showed that: 1) The developed method was sensitive and possessed good repeatability and high recovery rate, hence suitable for the quantitative analysis of 1,2-propylene glycol, glycerol and nicotine in the aerosol of e-cigarettes. 2) With the increase of device voltage from 3.7 to 6.9 V, the release of TPM, 1,2-propylene glycol, glycerol and nicotine in the aerosol increased, and the TPM release linearly correlated to the voltage (R2≥0.980 6). 3) The release of nicotine in the aerosol positively correlated to the concentration of nicotine in the e-liquids, the correlation between the release of nicotine and 1,2-propylene glycol in the aerosol was the closest (R2≥0.991 8), which indicated that 1,2-propylene glycol played an important role in nicotine delivery. 4) Variance analysis suggested that device voltage and nicotine concentration in the e-liquid significantly affected the release of nicotine in the aerosol, the influence degree of nicotine concentration in the e-liquid was slightly stronger than that of device voltage based on the values of partial η2.