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Recent Studies on Online Sample Preconcentration Methods inCapillary Electrophoresis Coupled with Mass Spectrometry

机译：毛细管电泳-质谱联用在线样品富集方法的最新研究

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This paper reviews recent 5-years application researches using online sample preconcentration (OSP) methods in capillary electrophoresis (CE) coupled with mass spectrometry (MS). CE-MS has excellent analytical features such as high-resolution separation, rapid analysis time, low sample consumption, and small consumption of organic solvents. Recently, low flow-rate interface for electrospray ionization has been developed and zmol-level sensitivity has been achieved. However, application of CE-MS has still been prevented due to small capacity of sample injection volume. OSP methods have been developed to address this issue and up to 5,000-fold sensitivity improvement was obtained so far. Various application has been carried out such as proteomics, metabolomics, and glycomics, and CE-MS attracts much attention as the highest-performance analytical tool for small-volume bioanalysis. Taking account of further progress in CE-MS, smart and practical application of OSP methods will be more important in various analytical fields.
机译：本文回顾了最近5年在毛细管电泳（CE）和质谱（MS）中使用在线样品预富集（OSP）方法的应用研究。 CE-MS具有出色的分析功能，例如高分辨率分离，快速分析时间，低样品消耗和有机溶剂消耗少。近来，已经开发出用于电喷雾电离的低流速界面，并且已经达到zmol水平的灵敏度。但是，由于样品进样体积小，因此仍无法使用CE-MS。已经开发出OSP方法来解决此问题，到目前为止，灵敏度提高了5,000倍。蛋白质组学，代谢组学和糖组学等已被广泛应用，CE-MS作为用于小体积生物分析的性能最高的分析工具引起了广泛的关注。考虑到CE-MS的进一步发展，在各种分析领域中OSP方法的智能和实际应用将变得更加重要。

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