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首页> 外文期刊>Chemotherapy Research and Practice >Protective Effect of Quercetin on Melphalan-Induced Oxidative Stress and Impaired Renal and Hepatic Functions in Rat
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Protective Effect of Quercetin on Melphalan-Induced Oxidative Stress and Impaired Renal and Hepatic Functions in Rat

机译：槲皮素对美法仑诱导的氧化应激和大鼠肾肝功能受损的保护作用

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One major challenge with the use of anticancer agents is the phenomenon of drug-induced toxicity. Melphalan (MPLN) is an alkylating anticancer agent, while quercetin (QCT) is an antioxidant. We investigated the protective role of quercetin against MPLN-induced toxicity. Twenty-five male Wistar rats (160–170 g) were randomized into five treatment groups; (I) control, (II) MPLN (0.2 mg/kg b.w.), (III) pre-treated with QCT (20 mg/kg b.w.) for 7 days followed by MPLN (0.2 mg/kg b.w.) for 7 days, (IV) cotreated with QCT (20 mg/kg b.w.) and MPLN (0.2 mg/kg b.w.) for 7 days, and (V) QCT (20 mg/kg b.w.) alone. MPLN caused a significant increase in plasma bilirubin, urea, and creatinine by 122.2%, 102.3%, and 188%, respectively (P<0.05). Similarly, plasma ALP, ALT, AST, andγ-GT activities increased significantly by 57.9%, 144.3%, 71.3%, and 307.2%, respectively, relative to control. However, pre or cotreatment with QCT ameliorated the levels of renal and hepatic function indices. Hepatic ascorbic acid and GSH and activities of glutathione-S-transferase, SOD, and catalase decreased significantly by 36.2%, 188%, 46.5%, 34.4%, and 55.2%, respectively, followed by increase in MDA content by 46.5% relative to control. Pre- and cotreatment with QCT reestablished the hepatic antioxidant status and lipid peroxidation. Overall, quercetin protected against MPLN-induced renal and hepatic toxicity in rats.
机译：使用抗癌药的主要挑战是药物诱导的毒性现象。美法仑（MPLN）是一种烷基化抗癌剂，而槲皮素（QCT）是一种抗氧化剂。我们调查了槲皮素对MPLN诱导的毒性的保护作用。将25只Wistar大鼠（160–170μg）随机分为五个治疗组; （I）对照，（II）MPLN（0.2μmg/ kg bw），（III）先用QCT（20μmg/ kg bw）预处理7天，再用MPLN（0.2μmg/ kg bw）预处理7天，（ IV）与QCT（20μmg/ kg bw）和MPLN（0.2μmg/ kg bw）共同处理7天，（V）与QCT（20μmg/ kg bw）单独处理。 MPLN导致血浆胆红素，尿素和肌酐分别显着增加122.2％，102.3％和188％（P <0.05）。同样，相对于对照组，血浆ALP，ALT，AST和γ-GT活性分别显着增加了57.9％，144.3％，71.3％和307.2％。但是，QCT的预治疗或共治疗可改善肾和肝功能指标的水平。肝抗坏血酸和谷胱甘肽以及谷胱甘肽-S-转移酶，SOD和过氧化氢酶的活性分别显着下降36.2％，188％，46.5％，34.4％和55.2％，其次是MDA含量相对于46％上升。控制。用QCT进行预处理和联合治疗可重新建立肝抗氧化剂状态和脂质过氧化作用。总体而言，槲皮素可防止MPLN诱导的大鼠肾脏和肝脏毒性。

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