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Using the Promise of Sonodynamic Therapy in the Clinical Setting against Disseminated Cancers

机译：在临床环境中使用声动力疗法对弥散性癌症的承诺

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Sonodynamic therapy (SDT) is a form of ultrasound therapy in which specialized chemotherapeutic agents known as sonosensitizers are administered to increase the efficacy of ultrasound-mediated preferential damage of neoplastic cells. Multiplein vitroandin vivostudies have indicated that SDT has the ability to exhibit profound physical and chemical changes on cellular structure. As supportive as the data have been, assessment of this method at the clinical level has been limited to only solid tumors. Although SDT has shown efficacy against multiple adherent neoplastic cell lines, it has also shown particular promise with leukemia-derived cell lines. Potential procedures to administer SDT to leukemia patients are heating the appendages as ultrasound is applied to these areas (Heat and Treat), using an ultrasound probe to scan the body for malignant growths (Target and Destroy), and extracorporeal blood sonication (EBS) through dialysis. Each method offers a unique set of benefits and concerns that will need to be evaluated in preclinical mammalian models of malignancy before clinical examination can be considered.
机译：声动力疗法（SDT）是超声疗法的一种形式，在这种超声疗法中，使用被称为声敏剂的专门化学治疗剂来提高超声介导的肿瘤细胞优先损伤的功效。多项体外和体内研究表明，SDT具有在细胞结构上表现出深刻的物理和化学变化的能力。尽管有数据支持，但在临床水平上对该方法的评估仅限于实体瘤。尽管SDT已显示出对多种粘附性肿瘤细胞系的功效，但它也显示出了白血病衍生细胞系的特殊前景。对超声波患者使用SDT的潜在程序是在将超声波施加到这些区域（加热和治疗）时加热附件，方法是使用超声波探头扫描人体的恶性生长（目标和破坏），然后通过体外血液超声（EBS）透析。每种方法都具有独特的益处和关注点，在考虑临床检查之前，需要在临床前的恶性哺乳动物模型中进行评估。

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