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首页> 外文期刊>Chemotherapy Research and Practice >Activity of Antimicrobial Peptides and Conventional Antibiotics against Superantigen PositiveStaphylococcus aureusIsolated from the Patients with Neoplastic and Inflammatory Erythrodermia
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Activity of Antimicrobial Peptides and Conventional Antibiotics against Superantigen PositiveStaphylococcus aureusIsolated from the Patients with Neoplastic and Inflammatory Erythrodermia

机译：肿瘤性和炎性红细胞增多症患者分离的抗菌肽和常规抗生素对超抗原阳性金黄色葡萄球菌的活性

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摘要

Superantigens are proteins comprising a group of molecules produced by various microorganisms. They are involved in pathogenesis of several human diseases. The aim of the study was the comparison of susceptibility to antibiotics and antimicrobial peptides (AMPs) ofStaphylococcus aureus(SA) strains producing staphylococcal enterotoxins SEA, SEB, SEC, SED, and TSST-1 and nonproducing ones. In the group of the total 28 of the patients with erythrodermia the presence of SA was confirmed in 24 cases. The total of 14 strains of SA excreted enterotoxins SEA, SEC, SED, and TSST-1. We did not observe that strains producing mentioned superantigens were less susceptible to AMPs (aurein 1.2, citropin 1.1, lipopeptide, protegrin 1, tachyplesin 3, temporin A, and uperin 3.6). The opposite situation was observed in conventional antibiotics. SA strains excreting tested superantigens had higher MICs and MBCs than nonproducing ones. The interesting finding considering the high efficacy of AMPs, against all examined strains of SA, makes them attractive candidates for therapeutic implication.
机译：超抗原是包含由各种微生物产生的一组分子的蛋白质。它们与几种人类疾病的发病机理有关。本研究的目的是比较产生葡萄球菌肠毒素SEA，SEB，SEC，SED和TSST-1以及非生产葡萄球菌肠毒素的金黄色葡萄球菌（SA）菌株对抗生素和抗菌肽（AMPs）的敏感性。在总共28例红细胞增多症患者中，有24例证实存在SA。总共14株SA排泄了肠毒素SEA，SEC，SED和TSST-1。我们没有观察到产生上述超抗原的菌株对AMPs的敏感性较低（金黄色素1.2，柠檬酸1.1，脂肽，protegrin 1，速激肽3，temporin A和uperin 3.6）。在常规抗生素中观察到相反的情况。排泄经测试的超抗原的SA菌株的MIC和MBC高于非生产菌株。考虑到AMPs对所有检测到的SA菌株均具有很高的功效，这一有趣发现使它们成为具有治疗意义的诱人候选物。

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