Antibiotic Combinations with Daptomycin for Treatment ofStaphylococcus aureusInfections

KristinaNadrah; FrancStrle

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Antibiotic Combinations with Daptomycin for Treatment ofStaphylococcus aureusInfections

机译：抗生素与达托霉素的组合治疗金黄色葡萄球菌感染

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Daptomycin is a lipopeptide antibiotic with a unique mechanism of action on Gram-positive bacteria. It is approved for treatment of skin and soft-tissue infections with Gram-positive bacteria, bacteraemia and right-sided infective endocarditis caused byStaphylococcus aureus. Diminishing susceptibility ofS. aureusto daptomycin during treatment of complicated infections and clinical failure have been described. Combinations of daptomycin with other antibiotics including gentamicin, rifampin, beta-lactams, trimethoprim/sulfamethoxazole (TMP-SMX), or clarithromycin present a new approach for therapy.In vitroand animal studies have shown that such combinations may, in some cases, be superior to daptomycin monotherapy. In this paper we focus on the antibiotic combinations for complicatedS. aureusinfections.

机译：达托霉素是一种脂肽抗生素，对革兰氏阳性细菌具有独特的作用机制。它被批准用于治疗由金黄色葡萄球菌引起的革兰氏阳性细菌，菌血症和右侧感染性心内膜炎的皮肤和软组织感染。 S的敏感性降低。已经描述了金黄色葡萄球菌达托霉素在复杂感染和临床失败的治疗过程中。达托霉素与庆大霉素，利福平，β-内酰胺类，甲氧苄氨嘧啶/磺胺甲基异恶唑（TMP-SMX）或克拉霉素的其他抗生素联合使用为一种新的治疗方法。达托霉素单药治疗。在本文中，我们重点研究复杂S的抗生素组合。金黄色葡萄球菌感染。

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《Chemotherapy Research and Practice》 |2011年第1期|共10页
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KristinaNadrah; FrancStrle;
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1. Daptomycin in combination with other antibiotics for the treatment of complicated Methicillin-resistant staphylococcus aureus bacteremia [J] . DhandA., SakoulasG. Clinical therapeutics . 2014,第10期

机译：达托霉素联合其他抗生素治疗耐甲氧西林的复杂金黄色葡萄球菌菌血症
2. Antibiotic treatment of enterococcal infections in gastroenterology with daptomycin first experiences from the EU-CORE registry study (european cubicin? outcomes registry and experience) [Antibiotische Therapie von Enterokokken-Infektionen in der Gastroenterologie mit Daptomycin erste Erfahrungen aus der Registerstudie EU-CORE (European Cubicin? Outcomes Registry and Experience)] [J] . LübbertC., WilhelmsD., WorlitzschD., Zeitschrift fur Gastroenterologie . 2012,第4期

机译：达托霉素在胃肠病学中用抗生素治疗肠球菌感染的初步经验来自于EU-CORE登记研究（欧洲立方蛋白？结局和经验）？结果注册表和经验）]
3. Daptomycin-oxacillin combinations in treatment of experimental endocarditis caused by daptomycin-nonsusceptible strains of methicillin-resistant Staphylococcus aureus with evolving oxacillin susceptibility (the "seesaw effect"). [J] . Yang SJ, Xiong YQ, Boyle Vavra S, Antimicrobial agents and chemotherapy. . 2010,第8期

机译：达托霉素-奥沙西林组合治疗由耐达西霉素的耐甲氧西林金黄色葡萄球菌菌株引起的实验性心内膜炎，并伴有不断增长的奥沙西林敏感性（“跷跷板效应”）。
4. Improvement of daptomycin yield by overexpression of ATP-binding cassette (ABC) transport proteins genes of daptomycin gene cluster [C] . Guanghai Yu, Yutao Min, Yuansen Hu, International Conference on Sustainable Energy and Environmental Engineering . 2013

机译：达达霉素基因簇的ATP结合盒（ABC）转运蛋白基因过表达改善达达霉素产量
5. Exploring novel daptomycin combinations with beta-lactam against susceptible & non-susceptible Enterococcus species. [D] . Raut, Animesh. 2015

机译：探索新型达托霉素与β-内酰胺类药物联合治疗易感和不易感肠球菌的可能性。
6. Antibiotic Combinations with Daptomycin for Treatment of Staphylococcus aureus Infections [O] . Kristina Nadrah, Franc Strle 2011

机译：抗生素与达托霉素的组合治疗金黄色葡萄球菌感染
7. Gentamicin in Combination with Ascorbic Acid Regulates the severity ofStaphylococcus aureusInfection-Induced Septic Arthritis in Mice [O] . P. Mal, S. Dutta, D. Bandyopadhyay, 2012

机译：庆大霉素与抗坏血酸的组合调节患有嗜昔有毒诱导的小鼠脓毒症关节炎的严重程度
8. Antibiotic and Clavulanic Acid Treatment of Subcutaneous Abscesses Caused by Bacteroides fragilis Alone or in Combination with Aerobic Bacteria [R] . Brook, I., Coolbaugh, J. C., Walker, R. I. 1983

机译：抗生素和克拉维酸治疗脆弱拟杆菌单独或与好氧细菌联合引起的皮下脓肿

Antibiotic Combinations with Daptomycin for Treatment ofStaphylococcus aureusInfections

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