Advances in Targeting HER3 as an Anticancer Therapy

NingJiang; Nabil F.Saba; Zhuo GeorgiaChen

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Advances in Targeting HER3 as an Anticancer Therapy

机译：靶向HER3作为抗癌治疗的进展

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HER3 (ErbB3) is a unique member of the human epidermal growth factor receptor (EGFR) family (ErbB family). It functions only through dimerization with other members of the ErbB family and modulates activity and sensitivity to targeted cancer therapies. This paper briefly describes the mechanism of HER3 in signal transduction and its potential role in acquired resistance to EGFR- and HER2-targeted therapies. We also consider recent developments in HER3-targeting therapeutics and their combination with inhibitors of other ErbB members in clinical applications.

机译：HER3（ErbB3）是人类表皮生长因子受体（EGFR）家族（ErbB家族）的独特成员。它仅通过与ErbB家族其他成员的二聚作用起作用，并调节对靶向癌症疗法的活性和敏感性。本文简要介绍了HER3在信号转导中的机制及其在针对EGFR和HER2靶向疗法获得性耐药中的潜在作用。我们还考虑了针对HER3的治疗方法的最新发展及其在临床应用中与其他ErbB成员抑制剂的组合。

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《Chemotherapy Research and Practice》 |2012年第1期|共9页
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NingJiang; Nabil F.Saba; Zhuo GeorgiaChen;
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中图分类临床医学;
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1. Increased Expression of HER2, HER3, and HER2:HER3 Heterodimers in HPV-Positive HNSCC Using a Novel Proximity-Based Assay: Implications for Targeted Therapies [J] . Pollock Netanya I., Wang Lin, Wallweber Gerald, Clinical cancer research: an official journal of the American Association for Cancer Research . 2015,第20期

机译：使用新型的基于邻近度的检测，HPV阳性HNSCC中HER2，HER3和HER2：HER3异二聚体的表达增加：靶向治疗的意义
2. Increased Expression of HER2, HER3, and HER2:HER3 Heterodimers in HPV-Positive HNSCC Using a Novel Proximity-Based Assay: Implications for Targeted Therapies [J] . Pollock Netanya I., Wang Lin, Wallweber Gerald, Clinical cancer research: an official journal of the American Association for Cancer Research . 2015,第20期

机译：使用新的基于接近的测定，HER2，HER3和HER2：HER3异二聚体在HPV阳性HNSCC中的表达：对靶向疗法的影响
3. Inhibition of EGFR, HER2, and HER3 signaling with AZD8931 in combination with anastrozole as an anticancer approach: Phase II randomized study in women with endocrine-therapy-na < ve advanced breast cancer [J] . Johnston Stephen, Basik Mark, Hegg Roberto, Breast cancer research and treatment. . 2016,第1期

机译：AZD8931联合阿那曲唑抑制EGFR，HER2和HER3信号传导作为一种抗癌方法：接受内分泌治疗且未患有晚期乳腺癌的女性的II期随机研究
4. ENGINEERING BACTERIAL NITROREDUCTASES FOR ANTICANCER GENE THERAPY AND TARGETED CELL ABLATION [C] . Abigail Sharrock, Elsie Williams, Kelsi Hall, Conference on biochemical and molecular engineering . 2019

机译：工程菌硝基还原酶用于抗癌基因治疗和靶向细胞消融
5. Classical antifolates: Synthesis of 5-substituted, 6-substituted and 7-substituted pyrrolo[2,3-d]pyrimidines as targeted anticancer therapies [D] . Wang, Yiqiang 2013

机译：经典抗叶酸药物：5取代，6取代和7取代的吡咯并[2,3-d]嘧啶的合成作为靶向抗癌药物
6. Advances in Targeting HER3 as an Anticancer Therapy [O] . Ning Jiang, Nabil F. Saba, Zhuo Georgia Chen 2012

机译：靶向HER3作为抗癌治疗的进展
7. Advances in Targeting HER3 as an Anticancer Therapy [O] . Ning Jiang, Nabil F. Saba, Zhuo Georgia Chen 2012

机译：靶向HER3作为抗癌治疗的进展

Advances in Targeting HER3 as an Anticancer Therapy

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