Focal Adhesion-Chromatin Linkage Controls Tumor Cell Resistance to Radio- and Chemotherapy

KatjaStorch; NilsCordes

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Focal Adhesion-Chromatin Linkage Controls Tumor Cell Resistance to Radio- and Chemotherapy

机译：局灶性粘附染色质联动控制肿瘤细胞对放射和化学疗法的抵抗力。

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Cancer resistance to therapy presents an ongoing and unsolved obstacle, which has clear impact on patient's survival. In order to address this problem, novelin vitromodels have been established and are currently developed that enable data generation in a more physiological context. For example, extracellular-matrix- (ECM-) based scaffolds lead to the identification of integrins and integrin-associated signaling molecules as key promoters of cancer cell resistance to radio- and chemotherapy as well as modern molecular agents. In this paper, we discuss the dynamic nature of the interplay between ECM, integrins, cytoskeleton, nuclear matrix, and chromatin organization and how this affects the response of tumor cells to various kinds of cytotoxic anticancer agents.

机译：癌症对治疗的耐药性是一个持续且尚未解决的障碍，对患者的生存有着明显的影响。为了解决这个问题，已经建立了新的体外模型，并且目前正在开发这种新模型，该模型能够在更生理的背景下生成数据。例如，基于细胞外基质（ECM-）的支架可鉴定出整联蛋白和整联蛋白相关的信号分子，这些分子是癌细胞对放射线和化学疗法以及现代分子药物耐药性的关键启动子。在本文中，我们讨论了ECM，整联蛋白，细胞骨架，核基质和染色质组织之间相互作用的动态性质，以及这如何影响肿瘤细胞对各种细胞毒性抗癌剂的反应。

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《Chemotherapy Research and Practice》 |2012年第1期|共10页
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KatjaStorch; NilsCordes;
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中图分类临床医学;
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1. A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy [J] . Canne Ian G., Merrick Karl A., Morandell Sandra, Cancer Cell . 2015,第5期

机译：多效性RNA结合蛋白控制不同的细胞周期检查点，以驱动p53缺陷型肿瘤对化疗的耐药性。
2. A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy (vol 28, pg 623, 2015) [J] . Cannell Ian G., Merrick Karl A., Morandell Sandra, Cancer Cell . 2015,第6期

机译：多亲RNA结合蛋白控制不同的细胞周期检查点，以驱动p53缺陷型肿瘤对化疗的耐药性（第28卷，第623页，2015年）
3. The combination of Bleomycin with TRAIL agonists or PKC inhibitors sensitizes solid tumor cells to BLM-mediated apoptosis: new strategies to overcome chemotherapy resistance of tumors [J] . Brahim Souhir, Aroui Sonia, Ali Rahamata, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2017,第9期

机译：博来霉素与TRAIL激动剂或PKC抑制剂的组合使实体肿瘤细胞敏化至BLM介导的细胞凋亡：克服肿瘤化疗抗性的新策略
4. Overcoming therapeutic resistance in pancreatic cancer is not a simple mix of PDT and chemotherapy: Evaluation of PDT-chemotherapy combinations in 3D tumor models [C] . Jonathan P. Celli, Ljubica Petrovic, Iqbal Massodi, Optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy XXII . 2013

机译：克服胰腺癌的治疗抗性不是PDT和化学疗法的简单组合：在3D肿瘤模型中评估PDT-化学疗法的组合
5. Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance. [D] . Khdair, Ayman Abed. 2008

机译：纳米粒子介导的化学疗法和光动力疗法相结合，克服了肿瘤的耐药性。
6. Focal Adhesion-Chromatin Linkage Controls Tumor Cell Resistance to Radio- and Chemotherapy [O] . Katja Storch, Nils Cordes 2012

机译：局灶性粘附染色质联动控制肿瘤细胞对放射和化学疗法的抵抗力。
7. A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy [O] . Cannell Ian G., Merrick Karl A., Morandell Sandra, 2015

机译：多效性RNA结合蛋白控制不同的细胞周期检查点，以驱动p53缺陷肿瘤对化疗的耐药性。

Focal Adhesion-Chromatin Linkage Controls Tumor Cell Resistance to Radio- and Chemotherapy

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