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Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents

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中文名称：药物化学研究：一种国际期刊，旨在就生物活性剂的设计和作用机理进行快速交流

ISSN：1054-2523
出版周期：-

发文量：3012

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1.CoMFA and CoMSIA analysis of protein kinase B (PKBbeta) inhibitors using various alignment methods

机译：使用各种比对方法对蛋白激酶B（PKBbeta）抑制剂进行CoMFA和CoMSIA分析
- 作者：Vivek K. Vyas;Nirzari Gupta;Manjunath Ghate
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2013年第12期
2.Chemico-biological investigation of rhizome essential oil of Zingiber moron-native to Northeast India

机译：印度东北部生姜的根茎精油的化学生物学研究
- 作者：Archana Das;Naresh Kasoju;Utpal Bora;Latha Rangan
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2013年第9期
- Camphene;
- Citral;
- Cytotoxicity;
- Linalool;
- Zingiber moran;
3.Molecular dynamic simulations of Co(III) and Ru(II) polypyridyl complexes and docking studies with dsDNA

机译：Co（III）和Ru（II）聚吡啶配合物的分子动力学模拟以及与dsDNA的对接研究
- 作者：Navaneetha Nambigari;Ramasree Dulapalli
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2013年第11期
- DNA;
- Molecular dynamic simulation;
- Docking;
- Major groove;
4.Molecular modelling studies on flavonoid derivatives as dual site inhibitors of human acetyl cholinesterase using 3D-QSAR, pharmacophore and high throughput screening approaches

机译：使用3D-QSAR，药效团和高通量筛选方法对类黄酮衍生物作为人乙酰胆碱酯酶的双位抑制剂进行分子建模研究
- 作者：Manisha Goyal;Sonam Grover;Jaspreet Kaur Dhanjal;Sukriti Goyal;Chetna Tyagi;Abhinav Grover
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第4期
- Acetyl cholinesterase;
- Alzheimer;
- QSAR;
- Pharmacophore;
- Natural;
- Docking;
- Dual;
5.Synthesis and biological evaluation of pyrrole-2-carboxamide derivatives: oroidin analogues

机译：吡咯-2-羧酰胺衍生物的合成及生物学评价：oroidin类似物
- 作者：Balaram S. Takale;Neha V. Desai;Afsar Ali Siddiki;Hemchra K. Chaudhari;Vikas N. Telvekar
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- Antibacterial;
- Bromination;
- Carboxamides;
- Esters;
- Pyrrole;
6.Optimization of phage heptapeptide library-screening process for developing inhibitors of the isocitrate lyase homologue from Mycobacterium tuberculosis

机译：用于开发结核分枝杆菌异柠檬酸裂合酶同源物抑制剂的噬菌体七肽文库筛选工艺的优化
- 作者：Xintao Liu;Yang Zang;Bo Sun;Yuhe Yin
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第5期
- Isocitrate lyase;
- Peptide;
- Inhibitor;
- Phage peptide library;
- Molecular docking;
- IC50;
7.Induction of apoptosis in lung adenocarcinoma and glioma cells by some oxadiazole derivatives

机译：恶二唑衍生物诱导肺腺癌和神经胶质瘤细胞凋亡
- 作者：Gulsen Akalin Ciftci;Safak Ulusoylar Yildirim;Mehlika Dilek Altmtop;Zafer Asim Kaplancikli
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第7期
- Oxadiazole;
- Anticancer activity;
- Apoptosis;
- Lung adenocarcinoma;
- Glioma;
8.Benzenesulfonamide bearing pyrazolylpyrazolines: synthesis and evaluation as anti-inflammatory-antimicrobial agents

机译：含苯甲磺酰胺的吡唑基吡唑啉类化合物：合成和评估作为抗炎抗菌剂
- 作者：Pawan Kumar;Navneet Chak;Pawan Kaushik;Chetan Sharma;Dhirender Kaushik;Kamal R. Aneja;Pawan K. Sharma
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第2期
- Pyrazolylpyrazolines;
- Chalcones;
- Antimicrobial activity;
- Anti-inflammatory activity;
- Benzenesulfonamide;
9.Synthesis and cytotoxicity studies of 3,5-diaryl N-acetyl pyrazoline-isatin hybrids

机译：3,5-二芳基N-乙酰基吡唑啉-靛红杂种的合成及细胞毒性研究
- 作者：Manmohan Sharma;Sahil Sharma;Abhishek Buddhiraja;A. K. Saxena;Kunal Nepali;P. M. S. Bedi
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第10期
- Molecular hybridization;
- Hybrids;
- Isatin;
- Cell lines;
- Cytotoxic;
10.Substituted phenyl containing l,3,4-oxadiazole-2-yl-but-2-enamides: synthesis and preliminary evaluation as promising anticonvulsants

机译：含1,3,4-恶二唑-2-基-丁-2-烯酰胺的苯基取代物：合成和初步评估为有前途的抗惊厥药
- 作者：Nadeem Siddiqui;Md. Jawaid Akhtar;M. Shahar Yar;Priya Ahuja;Waquar Ahsan;Sharique Ahmed
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第11期
- Epilepsy;
- Neurotoxicity;
- Pharmacophore;
- Liver enzyme estimation;
11.Synthesis, molecular properties and DFT studies of new phosphoramidates as potential urease inhibitors

机译：作为潜在脲酶抑制剂的新型氨基磷酸酯的合成，分子性质和DFT研究
- 作者：Fabricio M. Oliveira;Luiz C. A. Barbosa;Antonio J. Demuner
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第12期
- Urease inhibitors;
- Jack bean urease;
- Phosphoramidates;
- Canavalia ensiformis;
- DFT Studies;
12.Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives

机译：新型复杂的丁基芳基哌嗪-1-基衍生物的合成与结构评价
- 作者：Daniel Szulczyk;Anna Bielenica;Michat A. Dobrowolski;Lukasz Dobrzycki;Mariola Krawiecka
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- 5-HT_(1A) receptor;
- Arylpiperazines;
- X-ray crystallography;
- Diels-Alder reaction;
13.Synthesis, characterization, and biological activities of 4-imino-3-arylazo-4H-pyrimido[2,1-b][1,3]benzothiazole-2-oles

机译：4-亚氨基-3-芳基偶氮-4H-嘧啶基[2,1-b] [1,3]苯并噻唑-2-烯烃的合成，表征和生物学活性
- 作者：Selinay Eriskin;Nesrin Sener;Serkan Yavuz;Izzet Sener
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第8期
- Solvatochromism;
- Pyrimido benzothiazole;
- Diazo-coupling reaction;
- Azo dyes;
- Antimicrobial activity;
14.QSAR study of active human glucagon receptor antagonists by SW-MLR and SW-SVM methods

机译：SW-MLR和SW-SVM方法对活性人胰高血糖素受体拮抗剂的QSAR研究
- 作者：Javad Shadmanesh;Aiyoub Parchehbaf Jadid;Zhila Azari;Mehri Niazi;Mahdi Shahmohammadi Aghbolagh
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第5期
- QSAR;
- Multiple linear regression;
- Stepwise;
- Support vector machine;
- Human glucagon receptor;
15.Indolizine: a biologically active moiety

机译：吲哚嗪：具有生物活性的部分
- 作者：Vikas Sharma;Vipin Kumar
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第8期
- Biologically active;
- Camptothecin;
- Derivative;
- Heterocyclic;
- Indolizine;
- Moiety;
- Review;
16.Effect of garlic and cabbage on healing of gastric ulcer in experimental rats

机译：大蒜和白菜对实验性大鼠胃溃疡愈合的影响
- 作者：Taibi Ben Hadda;Naser A. ElSawy
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第12期
17.De novo design and in-silico studies of novel l-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid derivatives as HIV-1 reverse transcriptase inhibitors

机译：从头开始设计和计算机模拟研究新型1-苯基-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚-3-羧酸衍生物作为HIV-1逆转录酶抑制剂
- 作者：Ashok Penta;Subhash Cher;S. Ganguly;S. Murugesan
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第8期
- AIDS;
- HIV-1 reverse transcriptase;
- Docking;
- Molecular properties;
- Autodock;
18.Identification of neuraminidase inhibitors by structure-based screening: promising new leads for influenza

机译：通过基于结构的筛选鉴定神经氨酸酶抑制剂：有望成为流感新线索
- 作者：Soumendranath Bhakat;Faraz Shaikh;Siddharth Yadav;Rakesh M. Rawal
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第6期
- Neuraminidase inhibitor;
- Zanamivir;
- Influenza;
- Structure-activity relationship (SAR);
- Molecular docking;
19.Structural and energetic insights into the selective interactions of monoacylglycerol lipase with its natural substrate and small-molecule inhibitors

机译：对单酰基甘油脂肪酶与其天然底物和小分子抑制剂的选择性相互作用的结构和能量学见解
- 作者：Huayou Chen;Tengyun Sun;Hongzhang Chen;Rui Tian;Tianxi Zhang;Zhi Chen;Zhong Ni
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第5期
20.Synthesis and anticonvulsant activity evaluation of 7-alkoxy-2, 4-dihydro-1H-benzo[6][1,2,4]triazolo[4,3-d][1,4]thiazin-1-ones in various murine experimental seizure models

机译：7-烷氧基-2，4-二氢-1H-苯并[6] [1,2,4]三唑并[4,3-d] [1,4]噻嗪-1-酮的合成及其抗惊厥活性实验性癫痫发作模型
- 作者：Xu Cao;Shi-Ben Wang;Xian-Qing Deng;Da-Chuan Liu;Zhe-Shan Quan
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第4期
- Synthesis;
- Anticonvulsant;
- Triazolothiazinone;
- Maximal electroshock;
- Neurotoxicity;
21.Synergistic effects of berberines with antibiotics on clinical multi-drug resistant isolates of methicillin-resistant Staphylococcus aureus (MRSA)

机译：小碱与抗生素对耐甲氧西林金黄色葡萄球菌（MRSA）临床多重耐药菌株的协同作用
- 作者：Guo-Ying Zuo;Yang Li;Gen-Chun Wang;Zuo-Sheng Li;Jun Han
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第5期
- Anti-MRSA activity;
- Berberine;
- N-Methyl-dihydroberberine;
- Synergy;
- Azithromycin;
- Levofloxacin;
22.Apoptotic effect of synthetic 2',4',5'-trimethoxychalcones in human K562 and Jurkat leukemia cells

机译：合成的2'，4'，5'-三甲氧基查耳酮对人K562和Jurkat白血病细胞的凋亡作用
- 作者：Aline Costa;Louise Domeneghini Chiaradia-Delatorre;Lorena dos Santos Bubniak;Alessra Mascarello;Marley Apareeida Licinio Marzarotto;Ana Carolina Rabello de Moraes;Taisa Regina Stumpf;Marlon Norberto Sechini Cordeiro;Rosendo Augusto Yunes;Ricardo Jose Nunes;Maria Claudia Santos-Silva
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第10期
- Trimethoxychalcones;
- Cytotoxicity;
- Apoptotic effect;
- Leukemia;
- K562 cells;
- Jurkat cells;
23.Synthesis and characterization of novel benzimidazole bearing pyrazoline derivatives as potential antimicrobial agents

机译：新型吡唑啉衍生物苯并咪唑作为潜在抗菌剂的合成与表征
- 作者：N. C. Desai;D. D. Pya;G. M. Kotadiya;Priyanka Desai
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- Benzimidazole;
- Pyrazoline;
- Antibacterial activity;
- Antifungal activity;
24.Synthesis, characterization, and antibacterial activity of a novel heterocyclic Schiff's base and its metal complexes of first transition series

机译：新型杂环席夫碱及其第一过渡系列金属配合物的合成，表征和抗菌活性
- 作者：R. P. Saini;V. Kumar;A. K. Gupta;G. K. Gupta
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第2期
- Antibacterial activity;
- DHA;
- Tetra dentate Schiff base;
- Spectroscopy;
25.Does tautomerism influence the outcome of QSAR modeling?

机译：互变异构会影响QSAR建模的结果吗？
- 作者：Vijay H. Mas;Devidas T. Mahajan;Taibi Ben Hadda;Rahul D. Jawarkar;Ahmed M. Alafeefy
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第4期
26.Novel indolyl-pyrimidine derivatives: synthesis, antimicrobial, and antioxidant evaluations

机译：新型吲哚基-嘧啶衍生物：合成，抗菌和抗氧化剂评估
- 作者：Mosaad Sayed Mohamed;Mahmoud Moustafa Youns;Naglaa Mohamed Ahmed
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第7期
- Indolyl-pyrimidines;
- Antimicrobial;
- Antioxidant activity;
- Radical scavenging;
- SRB assay;
- Structure activity relationship;
27.New azetidine-3-carbonyl-N-methyl-hydrazino derivatives of fluoroquinolones: synthesis and evaluation of antibacterial and anticancer properties

机译：氟喹诺酮类新氮杂环丁烷-3-羰基-N-甲基肼基衍生物：抗菌和抗癌性能的合成与评价
- 作者：G. Govinda Rajulu;Halehatty S. Bhojya Naik;G. Charan Kumar;S. Ramaraj;Ganesh Sambasivam;Kesavan Poonimangadu Koppolu
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第6期
- Synthesis;
- Reductive amination;
- Fluoroquinolones;
- Antibacterial activity;
- Anticancer activity;
28.Microwave-assisted synthesis of benzimidazole bearing 1,3,4-oxadiazole derivatives: screening for their in vitro antimicrobial activity

机译：微波辅助合成含1,3,4-恶二唑衍生物的苯并咪唑：体外抗菌活性的筛选
- 作者：N. C. Desai;G. M. Kotadiya
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第9期
- Benzimidazole;
- Cytotoxicity;
- Microwave-assisted synthesis;
- MTT assay;
- 1;
- 3;
- 4-Oxadiazole;
29.Synthesis and in vitro cytotoxicity study of 3-(1H-indol-3-yl)-1,3-diphenylpropan-1-ones

机译：3-（1H-吲哚-3-基）-1,3-二苯基丙烷-1-酮的合成及体外细胞毒性研究
- 作者：Jagadeesh N. Masagalli;Kittappa M. Mahadevan;Honnali Jayadevappa;Hosanagara N. Harishkumar;Rajesha Ganalu;Prashantha Nagaraja
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第6期
- Michael addition;
- Indium(III) sulphate;
- Indole;
- Friedel-Crafts alkylation;
- Cytotoxic activity;
- SAR analysis;
30.Design, synthesis, and evaluation of novel l-methyl-3-substituted quinazoline-2,4-dione derivatives as antimicrobial agents

机译：设计，合成和评价新型的1-甲基-3-取代的喹唑啉-2,4-二酮类抗微生物剂
- 作者：Qing-Gang Ji;Dan Yang;Qiao Deng;Zhi-Qiang Ge;Lv-Jiang Yuan
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第5期
- Quinazoline-2;
- 4-dione;
- Amide;
- Antibacterial;
- Antifungal agents;
31.QSAR and pharmacophore modeling of diverse aminothiazoles and aminopyridines for antimalarial potency against multidrug-resistant Plasmodium falciparum

机译：多种氨基噻唑和氨基吡啶的QSAR和药效团模型对多重耐药性恶性疟原虫的抗疟药效力
- 作者：Rahul Balasaheb Aher;Kunal Roy
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第9期
- Aminothiazoles;
- Aminopyridines;
- Multidrug-resistance;
- Plasmodium falciparum;
- QSAR;
- 3D-pharmacophore;
32.Homology modeling, binding site identification, and docking study of human P-arrestin: an adaptor protein involved in apoptosis

机译：人P-arrestin的同源性建模，结合位点识别和对接研究：参与凋亡的衔接蛋白
- 作者：Chetan Chintha;Nirzari Gupta;Manjunath Ghate;Vivek K. Vyas
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- P-Arrestins;
- GPCRs;
- Homology modeling;
- Molecular docking;
- Apoptosis inducers;
33.A common binding mode that may facilitate the design of novel broad-spectrum inhibitors against metallo-beta-lactamases

机译：一种常见的结合模式，可能有助于设计针对金属β-内酰胺酶的新型广谱抑制剂
- 作者：Jiao Chen;Yifang Liu;Tianyi Cheng;Xingzhen Lao;Xiangdong Gao;Heng Zheng;Wenbing Yao
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第1期
34.One-pot synthesis and cytotoxic evaluation of amide-linked 1,4-disubstituted 1,2,3-bistriazoles

机译：酰胺连接的1,4-二取代的1,2,3-双三唑的一锅合成和细胞毒性评估
- 作者：Kashmiri Lai;C. P. Kaushik;Krishan Kumar;Ashwani Kumar;Asif Khurshid Qazi;Abid Hamid;Sundeep Jaglan
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第11期
- 1;
- 2;
- 3-Bistriazoles;
- Click chemistry;
- Cytotoxic activity;
- Docking simulation;
35.Synthesis of 5-benzyl-4-aryl-octahydro-1H-benzo[b][1,5]diazepin-2-ones as potent antidepressant and antimicrobial agents

机译：5-苄基-4-芳基-八氢-1H-苯并[b] [1,5]二氮杂-2-酮作为强效抗抑郁药和抗菌剂的合成
- 作者：Mariappan Babu;Kasi Pitchumani;Penugonda Ramesh
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第4期
- Benzodiazepines;
- Forced swim test;
- Disc diffusion method;
- Antidepressant;
- Antibacterial activity;
36.Synthesis and in vitro cholesteryl ester transfer protein inhibitory activity of novel esters of 2,10-dichloro-12H-dibenzo [d,g] 1,3-dioxocin-6-carboxylic acid

机译：2,10-二氯-12H-二苯并[d，g] 1,3-二恶英-6-羧酸新型酯的合成及其体外胆固醇酯转移蛋白抑制活性
- 作者：Sirishadevi Talluri;Suvarna G. Kini;Ajit Kale;Ganesh Kumar;Renu Ohlyan
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第10期
- Cholesteryl ester transfer protein (CETP);
- 2;
- 10-Dichloro-12H-dibenzo d;
- g 1;
- 3 dioxocin-6-carboxylic acid;
- In vitro activity;
37.Zeaoxazolinone, a new antifungal agent from Zea mays roots

机译：玉米杂草根中的新型抗真菌剂玉米杂恶唑啉酮
- 作者：Gamal A. Mohamed;Sabrin R. M. Ibrahim;Mohamed S. A. Abdelkader;Nawal M. Al-Musayeib;Mohamed Ghoneim;Samir A. Ross
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第10期
- Zea mays;
- Gramineae;
- Benzoxazolinone;
- Zeaoxazolinone;
- Antifungal;
38.Chemical composition of Hypogymnia physodes lichen and biological activities of some its major metabolites

机译：失眠的地衣的化学成分及其主要代谢产物的生物活性
- 作者：Branislav Rankovic;Marijana Kosanic;Nedeljko Manojlovic;Aleksar Rancic;Tatjana Stanojkovic
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第1期
- Hypogymnia physodes;
- Lichen metabolites;
- Antioxidant activity;
- Antimicrobial activity;
- Anticancer activity;
39.Antimicrobial and antiquorum-sensing studies. Part 2: synthesis, antimicrobial, antiquorum-sensing and cytotoxic activities of new series of fused [1,3,4]thiadiazole and [1,3]benzothiazole derivatives

机译：抗菌和抗群体感应研究。第2部分：新系列的[1,3,4]噻二唑和[1,3]苯并噻唑衍生物的融合系列的合成，抗菌，抗群体感应和细胞毒活性
- 作者：N. S. El-Gohary;M. I. Shaaban
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第1期
40.Evaluation of phytocannabinoids from high-potency Cannabis sativa using in vitro bioassays to determine structure-activity relationships for cannabinoid receptor 1 and cannabinoid receptor 2

机译：使用体外生物测定法评估高效大麻中的植物大麻素，以确定大麻素受体1和大麻素受体2的结构活性关系
- 作者：Afeef S. Husni;Christopher R. McCurdy;Mohamed M. Radwan;Safwat A. Ahmed;Desmond Slade;Samir A. Ross;Mahmoud A. ElSohly;Stephen J. Cutler
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第9期
- Cannabis;
- Tetrahydrocannabinol;
- Structure-activity relationship;
- Cannabinoid;
- Cannabinoid receptor 1;
- Cannabinoid receptor 2;
41.In vitro anti-nitrosative, antioxidant, and cytotoxicity activities of plant flavonoids: a comparative study

机译：植物类黄酮的体外抗亚硝化，抗氧化剂和细胞毒性活性：一项比较研究
- 作者：Hanem M. Awad;Howaida I. Abd-Alla;Khaled H. Mahmoud;Sayed A. El-Toumy
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第7期
- Nitric oxide;
- Peroxynitrite;
- Nitrous acid;
- Cytotoxicity;
- DPPH;
- Flavonoids;
42.Synthesis of new thiazolo[3,2-b] [1,2,4] triazole-6(5H)-one derivatives as potent analgesic and anti-inflammatory agents

机译：新型噻唑[3,2-b] [1,2,4]三唑-6（5H）-one衍生物的合成作为有效的止痛和消炎药
- 作者：Mohammad Javad Assarzadeh;Ali Almasirad;Abbas Shafiee;Mansur Nassiri Koopaei;Mohammad Abdollahi
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第2期
- Analgesic agents;
- Anti-inflammatory activity;
- Thiazolo-triazole;
- Ulcerogenic activity;
43.Synthesis, molecular docking and antiviral screening of novel N'-substitutedbenzylidene-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]tMazin-1(4H)-yl) acetohydrazides

机译：新型N'-取代的亚苄基-2-（4-甲基-5,5-二氧化-3-苯并[e]吡唑并[4,3-c] [1,2] tMazin-1（）的合成，分子对接和抗病毒筛选4H）-yl）乙酰肼
- 作者：Sana Aslam;Matloob Ahmad;Muhammad Makshoof Athar;Usman Ali Ashfaq;John M. Gardiner;Catherine Montero;Mervi Detorio;Masood Parvez;Raymond F. Schinazi
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第6期
- Anti-HIV-1 activity;
- 1;
- 2-Benzothiazine;
- Cytotoxic activity;
- Hydrazides;
- Pyrazolobenzothiazine dioxides;
44.Synthesis and antimicrobial evaluation of 1,3,4-oxadiazole-based chalcone derivatives

机译：1,3,4-恶二唑基查尔酮衍生物的合成及抗菌性能评价
- 作者：Deepkumar Joshi;Kalpesh Suryakant Parikh
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第4期
- Chalcones;
- 1;
- 3;
- 4-Oxadiazole;
- Antifungal activity;
- Antibacterial activity;
- MIC;
45.Type II diabetes-related enzyme inhibition and molecular modeling study of a novel series of pyrazolone derivatives

机译：新型吡唑酮衍生物系列的II型糖尿病相关酶抑制和分子模型研究
- 作者：Shobhitha Shetty;Balakrishna Kalluraya;Nithinchra;S. K. Peethambar;Seep B. Telkar
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第6期
- Pyrazolone;
- Green technique;
- Antidiabetic;
- alpha-Amylase inhibition;
- In silico molecular modeling study;
46.Development of amino acid conjugated sulfonamides as potent antiulcer agent

机译：氨基酸共轭磺酰胺类抗溃疡药的研制
- 作者：Shakti Prasanna Sahoo;Bharat Bhusan Subudhi
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第6期
- Amino acid;
- Sulfonamide;
- Conjugate;
- Antiulcer;
- H~+/K~+ ATPase;
47.Synthesis, antimicrobial, and anticancer evaluation of novel 2-(3-methylindolyl)benzimidazole derivatives

机译：新型2-（3-甲基吲哚基）苯并咪唑衍生物的合成，抗菌和抗癌性评估
- 作者：P. N. Kishore Babu;B. Ramadevi;Y. Poornachra;C. Ganesh Kumar
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第9期
- 2-(3-Methyl-indolyl)-benzimidazole derivatives;
- N-alkylations;
- Gram-positive bacteria;
- Cytotoxicity;
48.Synthesis of novel spin-labeled podophyllotoxin derivatives as potential antineoplastic agents: Part XXV

机译：新型自旋标记鬼臼毒素衍生物作为潜在抗肿瘤药的合成：第二十五部分
- 作者：Liu Yang;Xiang Nan;Wen-Qun Li;Mei-Juan Wang;Xiao-Bo Zhao;Ying-Qian Liu;Zhi-Jun Zhang;Kuo-Hsiung Lee
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第11期
- Podophyllotoxin;
- Click chemistry;
- Cytotoxic activity;
- Spin-labeled;
49.Synthesis, antimicrobial, and cytotoxicity studies of novel sulfur-linked quinoline-coumarin bisheterocycles

机译：新型硫连接的喹啉-香豆素双歧双杂环化合物的合成，抗菌和细胞毒性研究
- 作者：Nidhin Paul;Shanmugam Muthusubramanian
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- Friedlander annulation;
- Quinoline;
- Coumarin;
- Antimicrobial activity;
- Cytotoxicity;
50.Inhibitory effect of N-ethyl-3-amino-5-oxo-4-phenyl-2,5-dihydro-1H-pyrazole-1-carbothioamide on Haemophilus spp. planktonic or biofilm-forming cells

机译：N-乙基-3-氨基-5-氧代-4-苯基-2,5-二氢-1H-吡唑-1-碳硫酰胺对嗜血杆菌的抑制作用。浮游或生物膜形成细胞
- 作者：Urszula Kosikowska;Anna Malm;Monika Pitucha;Barbara Rajtar;Malgorzata Polz-Dacewicz
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第2期
- Haemophilus spp.;
- Pyrazole derivatives;
- Antibacterial activity;
- Anti-biofilm activity;
- Cytotoxicity;
51.Antiproliferative effects of novel urea derivatives against human prostate and lung cancer cells; and their inhibition of beta-glucuronidase activity

机译：新型尿素衍生物对人前列腺和肺癌细胞的抗增殖作用;及其对β-葡萄糖醛酸苷酶活性的抑制
- 作者：Shahnaz Perveen;Sana Mustafa;Kehkashan Qamar;Ahsana Dar;Khalid M. Khan;Muhammad Iqbal Choudhary
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- Urea derivatives;
- Prostate cancer (PC-3) cell line;
- Lung cancer (NCI-H460) cell line;
- beta-Glucuronidase;
- Urease;
- Phosphodiesterase;
52.In-silico analysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK): a potential drug target against Salmonella enterica serovar typhi

机译：硅内分析6-羟甲基-7,8-二氢蝶呤焦磷酸激酶（HPPK）：对抗肠炎沙门氏菌血清型伤寒的潜在药物靶标
- 作者：Malathy Palayam;Malarvizhi Panneerselvam Gunasekaran Krishnaswamy
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第2期
53.Synthesis, characterization and preliminary anticonvulsant evaluation of some flavanone incorporated semicarbazides

机译：某些结合了黄烷酮的氨基脲的合成，表征和初步的惊厥评价
- 作者：C. S. Sharma;T. Verma;H. P. Singh;N. Kumar
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第11期
- Flavones;
- Semicarbazone;
- Anticonvulsant;
- Mes;
- In silico neurotoxicity;
- Tpsa;
54.Synthesis and biological evaluation of a novel ONS tridentate Schiff base bearing pyrimidine ring and some metal complexes

机译：新型带有嘧啶环和某些金属配合物的ONS三齿席夫碱的合成及生物学评价
- 作者：Mehmet Sonmez;Hatice Gamze Sogukomerogullari;Feyza Oztemel;Ismet Berber
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第7期
- Pyrimidine-2-thione;
- 5-Chloro-2-hydroxyacethophenone;
- Schiff base metal complexes;
- Biological studies;
55.Prospective atom-based 3D-QSAR model prediction, pharmacophore generation, and molecular docking study of carbamate derivatives as dual inhibitors of AChE and MAO-B for Alzheimer's disease

机译：前瞻性基于原子的3D-QSAR模型预测，药效基团产生和氨基甲酸酯衍生物作为AChE和MAO-B双重抑制剂对阿尔茨海默氏病的预测，分子对接研究
- 作者：Vikas Kumar;Nidhi Chadha;Anjani K. Tiwari;Neeta Sehgal;Anil K. Mishra
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- 3D-QSAR;
- AChE;
- MAO-B;
- Alzheimer's disease;
56.^d>Department of Chemistry, Maharashtra Udayagiri Mahavidyalaya, Udgir, India

机译：^ d>化学系，马哈拉施特拉邦Udayagiri Mahavidyalaya，乌吉尔，印度
- 作者：Girish D. Hatnapure;Ashish P. Keche;Atish H. Rodge;Rajesh H. Tale;Satish S. Birajdar;Mahendra J. Pawar;Vana M. Kamble
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第1期
- Flavonoid;
- NSAIDs;
- ALGAR-FLYNN-OYAMADA anti-inflammatory and antimicrobial activities;
57.Synthesis, anti-inflammatory evaluation, and docking studies of some new thiazole derivatives

机译：一些新型噻唑衍生物的合成，抗炎评估和对接研究
- 作者：Pran Kishore Deb;Rajwinder Kaur;Balakumar Chrasekaran;Madhu Bala;Dilshad Gill;Venkat Rao Kaki;Raghuram Rao Akkinepalli;Raghuprasad Mailavaram
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第6期
58.POM analyses for antimicrobial evaluation of thienopyrimidinones derivatives: a rapid method for drug design

机译：POM分析对噻吩并嘧啶酮类衍生物的抗菌作用：药物设计的快速方法
- 作者：Taibi Ben Hadda;Mushtaq Ahmad;Shazia Sultana;Usama Shaheen;Ammar Bader;Sajal Srivastava;Barnali Das;Hector Salgado-Zamora
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第1期
59.Synthesis and antimicrobial screening of some novel ehalcones and flavanones substituted with higher alkyl chains

机译：某些被高级烷基链取代的新型卤代烷和黄烷酮的合成与抗菌筛选
- 作者：Uppuluri Venkata Mallavadhani;Laxmidhar Sahoo;Koochana Pranay Kumar;Upadyayula Suryanarayana Murty
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第6期
- Chalcones;
- Flavanones;
- Nonyl chalcones;
- Nonyl flavanones;
- Dodecyl chalcones;
- Dodecyl flavanones;
- Antibacterial activity;
- Antifungal activity;
60.Synthesis and in vitro antiproliferative evaluation of 3-acyl-2-arylamino-1,4-naphthoquinones

机译：3-酰基-2-芳基氨基-1,4-萘醌的合成及体外抗增殖评价
- 作者：David Rios;Julio Benites;Felipe Torrejon;Cristina Theoduloz;Jaime A. Valderrama
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第9期
- Acylquinones;
- Half-wave potential;
- Donor-acceptor compounds;
- Antiproliferative activity;
61.Anti-HIV-1 screening of (2E)-3-(2-chloro-6-methyl/ methoxyquinolin-3-yl)-1-(aryl)prop-2-en-l-ones

机译：（2E）-3-（2-氯-6-甲基/甲氧基喹啉-3-基）-1-（芳基）丙-2-烯-1-酮的抗HIV-1筛选
- 作者：Syed Umar Farooq Rizvi;Matloob Ahmad;Mujahid Hussain Bukhari;Catherine Montero;Payel Chatterjee;Mervi Detorio;Raymond F. Schinazi
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第1期
- Heterocyclic compounds;
- Quinolyl chalcones;
- Arylketone;
- Cytotoxicity;
- Anti-HIV-1 activity;
62.Design, synthesis, crystal structure, bioactivity, and molecular docking studies of novel sulfonylamidine-derived neonicotinoid analogs

机译：新型磺酰lam衍生的新烟碱类似物的设计，合成，晶体结构，生物活性和分子对接研究
- 作者：Liu Yang;Yong-Long Zhao;Chun-Yan Zhao
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第12期
63.Design, synthesis and docking studies of 2-benzoxazolinone-based 1,2,4-triazoles as proinflammatory cytokine inhibitors

机译：设计，合成和对接研究基于2-苯并恶唑啉酮的1,2,4-三唑类作为促炎细胞因子抑制剂
- 作者：Saqlain Haider;Mohammad Sarwar Alam;Hinna Hamid;Abhijeet Dhulap;Sadiq Umar;Mohammad Shahar Yar;Sameena Bano;Syed Nazreen;Yakub Ali;Chetna Kharba
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第9期
- Cyclooxygenase;
- Molecular docking;
- Antinociceptive;
- 2AZ5 ligand;
64.Synthesis and antibacterial activity evaluation of 2,6-bis(6-substituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-3-yl)pyridine derivatives

机译：2,6-双（6-取代-1,2,4-三唑[3,4-b] [1,3,4]噻二唑-3-基）吡啶衍生物的合成及抗菌活性评价
- 作者：Haihua Xiao;Pingliang Li;Dongcai Guo;Jinhui Hu;Yuchao Chai;Wei He
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第4期
- Pyridine-2;
- 6-dicarboxylic acid derivatives;
- 1;
- 2;
- 4-Triazole;
- Synthesis;
- Antibacterial activity;
65.Anti-mycobacterial, cytotoxic activities of Knoevenagel and (E)-alpha,beta-unsaturated esters and ketones from 2-chloronicotinaldehydes

机译：2-氯烟碱中Knoevenagel和（E）-α，β-不饱和酯和酮的抗分枝杆菌的细胞毒活性
- 作者：Pathi Suman;Rayala Nageswara Rao;Bhimapaka China Raju;Dharmarajan Sriram;Pulla Venkat Koushik
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第1期
66.Design, synthesis, molecular docking, and biological evaluation of N-methyl-3-nitro-4-(nitromethyl)-4H-chromen-2-amine derivatives as potential anti-cancer agents

机译：N-甲基-3-硝基-4-（硝基甲基）-4H-铬-2-胺衍生物作为潜在抗癌药的设计，合成，分子对接和生物学评估
- 作者：A. Parthiban;J. Muthukumaran;A. Moushumi Priya;S. Jayachran;R. Krishna;H. Surya Prakash Rao
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第2期
- 4H-chromene;
- Anti-apoptotic proteins;
- Molecular docking;
- Cytotoxicity;
67.Predictive 3D-QSAR and HQSAR model generation of isocitrate lyase (ICL) inhibitors by various alignment methods combined with docking study

机译：通过各种比对方法结合对接研究预测3D-QSAR和HQSAR模型生成异柠檬酸裂解酶（ICL）抑制剂
- 作者：Nirzari Gupta;Vivek K. Vyas;Bhumika Patel;Manjunath Ghate
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第6期
- Isocitrate lyase (ICL);
- CoMFA;
- CoMSIA;
- Hologram QSAR;
- Distil;
- Docking;
- Mycobacterium tuberculosis;
- Tripos;
68.New aminoadamantane derivatives with antiproliferative activity

机译：具有抗增殖活性的新型氨基金刚烷衍生物
- 作者：Ioannis Papanastasiou;Andrew Tsotinis;Nicolas Kolocouris;Spyros P. Nikas;Alexre Vamvakides
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第4期
- Aminoaromatic adamantanes;
- Synthesis;
- Antiproliferative activity;
69.Novel S-triazine accommodated 5-benzylidino-4-thiazolidinones: synthesis and in vitro biological evaluations

机译：新型S-三嗪可容纳5-苄基亚基-4-噻唑烷酮：合成和体外生物学评估
- 作者：Aniruddhasinh M. Rana;Pooja Trivedi;Kishor R. Desai;Smita Jauhari
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第10期
- S-triazine;
- 5-Benzylidino-4-thiazolidinone;
- SAR study;
- Antituberculosis activity;
- Antimicrobial activity;
70.Synthesis, cytotoxic evaluation, and molecular docking study of 4,5-diaryl-thiazole-2-thione analogs of combretastatin A-4 as microtubule-binding agents

机译：康布雷他汀A-4作为微管结合剂的4,5-二芳基-噻唑-2-硫酮类似物的合成，细胞毒性评估和分子对接研究
- 作者：Marjan Salehi;Seyed Nasser Ostad;Gholam Hossein Riazi;Amir Assadieskar;Tayebeh Cheraghi-Shavi
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- 4;
- 5-Diaryl-thiazole;
- Tubulin;
- Cytotoxicity;
- Molecular docking;
71.Pharmacophore modeling and 3D-QSAR studies of leucettines as potent Dyrk2 inhibitors

机译：亮氨酸作为有效的Dyrk2抑制剂的药理学建模和3D-QSAR研究
- 作者：Anu Bahl;Prashant Joshi;Sip B. Bharate;Harish Chopra
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第4期
- Anti-Alzheimer;
- Pharmacophore model;
- QSAR;
- Dyrk2;
- Partial least square analysis;
- Leucettines;
72.Synthesis, cytotoxicity, and DNA-binding property of berberine derivatives

机译：小ber碱衍生物的合成，细胞毒性和DNA结合特性
- 作者：Cui Liu;Siyuan Liu;Yuechai Wang;Shuxiang Wang;Jinchao Zhang;Shenghui Li
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第4期
- 9-Substituted berberine derivatives;
- Cytotoxicity;
- DNA binder;
73.Fluoroquinolones: novel class of gastrointestinal dietary lipid digestion and absorption inhibitors

机译：氟喹诺酮类：胃肠道饮食中新型脂质消化吸收抑制剂
- 作者：Yusuf M. Al-Hiari;Violet N. Kasabri;Ashok K. Shakya;Muhammad H. Alzweiri;Fatma U. Afifi;Yasser K. Bustanji;Ihab M. Al-Masri
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第7期
- Fluoroquinolone;
- Molecular modeling;
- 1H-quino7;
- 8-b1;
- 4benzodiazepine-3-carboxylic acid;
- Pancreatic triacylglycerol lipase inhibitor;
- Orlistat;
- Ciprofloxacin;
74.Studies on the inhibitory models of pyrazoline derivatives as EGFR. kinase inhibitors by 3D-QSAR and molecular docking

机译：吡唑啉衍生物作为EGFR的抑制模型研究。 3D-QSAR和分子对接的激酶抑制剂
- 作者：Peizhen Li;Yueli Tian;Honglin Zhai;Fangfang Deng;Meihong Xie;Xiaoyun Zhang
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第6期
- Pyrazole derivatives;
- EGFR inhibitors;
- 3D-QSAR;
- CoMFA;
- CoMSIA;
- Molecular docking;
75.Molecular modeling of a series of pyridinecarboxamidrazone-azole derivatives with antifungal activity

机译：一系列具有抗真菌活性的吡啶甲酰胺基吡唑衍生物的分子模型
- 作者：Luciana Terra;Helena Carla Castro
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第12期
- Antifungal;
- Molecular modeling;
- Triazole derivatives;
- Imidazole derivatives;
76.Synthesis and evaluation of some semicarbazone-and thiosemicarbazone-based cathepsin B inhibitors

机译：某些基于半碳素和硫半碳素的组织蛋白酶B抑制剂的合成和评价
- 作者：Neera Raghav;Ravinder Kaur
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第11期
- Cathepsin B;
- Inhibitors;
- Semicarbazones;
- Thiosemicarbazones;
- Kinetic studies;
77.Evaluation of insecticidal activity of camptothecin analogs against Brontispa longissima

机译：喜树碱类似物对长白僵菌的杀虫活性评估
- 作者：Liu Yang;Zhi-Jun Zhang;Ying-Qian Liu;Chun-Yan Zhao;Mei-Juan Wang;Xiang Nan;Gang Feng
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第2期
- Camptothecin;
- Insecticidal activity;
- Brontispa longissima;
- Structure-activity relationships;
78.Comparative modeling and molecular docking studies of D-Alanine:D-alanine ligase: a target of antibacterial drugs

机译：D-丙氨酸的比较建模和分子对接研究：D-丙氨酸连接酶：抗菌药物的靶标
- 作者：Syed Siker Azam;Sumra Wajid Abbasi;Amina Saleem Akhtar;Mah-laka Mirza
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第9期
- Antibacterial drug target;
- Comparative modeling;
- Molecular docking;
- Protein-ligand interactions;
79.Chemical synthesis, molecular modelling, and evaluation of anticancer activity of some pyrazol-3-one Schiff base derivatives

机译：吡唑-3-一席夫碱衍生物的化学合成，分子建模和抗癌活性评估
- 作者：Salah M. Bensaber;H. A. Allafe;Nouri B. Ermeli;Salah B. Mohamed
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第12期
80.Isolation and characterization of new secondary metabolites from Asphodelus microcarpus

机译：小果拟白粉菌新次级代谢产物的分离与鉴定
- 作者：Mohammed M. Ghoneim;Khaled M. Elokely;Atef A. El-Hela;Abd Elsalam I. Mohammad;Melissa Jacob;Stephen J. Cutler;Robert J. Doerksen;Samir A. Ross
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第7期
- Asphodelus microcarpus;
- Asphodalaceae;
- Electronic circular dichroism;
- Isochromene;
- MRSA;
81.Synthesis of progesterone derivatives and evaluation of their efficiency as pneumococcal vaccines

机译：孕酮衍生物的合成及其作为肺炎球菌疫苗的功效评估
- 作者：Rafat M. Mohareb;Fatma O. Al Farouk;Sherif M. Sherif;Konstantin Karaghiosoff
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第6期
- Pneumococcal vaccines;
- Progesterone;
- Pyrazole;
- Thiophene;
- Pyran;
- Arylhydrazone;
- Benzylidene;
82.Antimicrobial, DNA cleavage, and antioxidant properties of new series of metal(II) complexes derived from naphthofuran-2-carbohydrazide Schiff base: synthesis and physico-chemical studies

机译：萘呋喃-2-碳酰肼席夫碱衍生的新系列金属（II）配合物的抗菌，DNA裂解和抗氧化性能：合成和理化研究
- 作者：M. B. Halli;R. B. Sumathi
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第4期
- Naphthofuran Schiff base;
- Complexes;
- Characterization;
- Antimicrobial;
- Antioxidant;
- DNA cleavage;
83.Synthesis and antibacterial evaluation of 3,3-diindolylmethane derivatives

机译：3,3-二吲哚基甲烷衍生物的合成及抗菌性能评价
- 作者：Sutapa Roy;Rahul Gajbhiye;Madhumita Mal;Churala Pal;Arumugam Meyyapan
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- Diindolylmethane;
- Antibacterial activity;
- MIC;
- Hemolytic activity;
- Cytotoxicity;
84.Modification of carboxylated multiwall nanotubes with benzotriazole derivatives and study of their anticancer activities

机译：苯并三唑衍生物对羧基化多壁纳米管的改性及其抗癌活性的研究
- 作者：Mahdieh Entezari;Mojdeh Safari Malak Hekmati;Shohreh Hekmat Atena Azin
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第1期
- Carboxylated multiwall nanotubes;
- Functionalization;
- Characterization;
- Cell line;
- Antitumor activity;
85.Biotransformation of artemisinin derivatives by Glycyrrhiza glabra, Lavandula officinalis, and Panax quinquefolium

机译：甘草，薰衣草和西洋参对青蒿素衍生物的生物转化
- 作者：Rashmi Gaur;Suman Patel;Ram Kishor Verma;Archana Mathur;Rajendra Singh Bhakuni
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- Plant cells;
- a-Artemether;
- Dihydroartemisinin;
- Metabolites;
- Biotransformation;
86.Oligoamides of 2-amino-5-alkylthiazole 4-carboxylic acids: anti-trypanosomal compounds

机译：2-氨基-5-烷基噻唑4-羧酸的低聚酰胺：抗锥虫类化合物
- 作者：Stuart Lang;Abedawn I. Khalaf;David Breen;Judith K. Huggan;Carol J. Clements;Simon P. MacKay;Colin J. Suckling
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- DNA;
- Minor groove binder;
- Amide;
- Thiazole;
- Anti-parasitic activity;
87.Synthesis of novel fluoro 1,2,3-triazole tagged amino bis(benzothiazole) derivatives, their antimicrobial and anticancer activity

机译：新型含氟1,2,3-三唑标记的氨基双（苯并噻唑）衍生物的合成，抗菌和抗癌活性
- 作者：Ravindra M. Kumbhare;Tulshiram L. Dadmal;R. Pamanji;Umesh B. Kosurkar;L. R. Velatooru;K. Appalanaidu;Y. Khageswara Rao;J. Venkateswara Rao
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第10期
88.Synthesis and pharmacological evaluation of novel thienopyrimidine and triazolothienopyrimidine derivatives

机译：新型硫代嘧啶和三唑并噻吩并嘧啶衍生物的合成及药理评价
- 作者：Jameel Ahmed S. Mulla;Mohammed Iqbal A. Khazi;Shridhar I. Panchamukhi;Young-Dae Gong;Imtiyaz Ahmed M. Khazi
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第6期
- Thienopyrimidine;
- Triazolothienopyrimidine;
- Gewald reaction;
- Analgesic;
- Anti-inflammatory;
- Antibacterial activity;
89.Synthesis of some benzoxazinyl pyrazolone arylidenes as potent antimicrobials and antioxidants

机译：某些苯并恶嗪基吡唑啉酮芳烃的合成作为有效的抗微生物剂和抗氧化剂
- 作者：George Sonia;Knolin K. Thachil;Manoj Kumar Parameswaran;Ravi Thengungal Kochupappy
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- Benzoxazine;
- Pyrazole;
- Knoevengel condensation;
- Antimicrobial activity;
- Antioxidant activity;
90.Synthesis, biological activities, and pharmacokinetics studies of a mutual prodrug of aceclofenac and paracetamol

机译：醋氯芬酸与扑热息痛的互用前药的合成，生物学活性和药代动力学研究
- 作者：Asif Husain;Priyanka Ahuja;M. Shaharyar;Aftab Ahmad;Ibraheem Ahmed I. Mkhalid
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- Mutual prodrug;
- Aceclofenac;
- Paracetamol;
- Pharmacokinetics;
91.Xanthones with anti-tumor activity isolated from Securidaca inappendiculata

机译：从附生无血草（Securidaca inappendiculata）中分离出的具有抗肿瘤活性的黄嘌呤
- 作者：Jian Zuo;Kun-jun Mao;Fei Yuan;Xiang Li;Jian-wei Chen
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第11期
- Xanthone;
- Securidaca inappendiculata;
- Isolation;
- Anti-tumor;
- Structure-activity relation analysis;
92.Synthesis, anti-inflammatory and antioxidant activity of ring-A-monosubstituted chalcone derivatives

机译：环A-单取代查尔酮衍生物的合成，抗炎和抗氧化活性
- 作者：Hiba Iqbal;Visakh Prabhakar;Atul Sangith;Baby Chrika;Ranganathan Balasubramanian
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第10期
- Chalcone;
- Antioxidant;
- Anti-inflammatory;
- Sulphonamide;
- Protein denaturation;
- DPPH;
93.Efficient synthesis, anticonvulsant and muscle relaxant activities of new 2-((5-amino-1,3,4-thiadiazol-2-yl)methyl)-6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives

机译：2-（（5-氨基-1,3,4-噻二唑-2-基）甲基）-6-苯基-4,5-二氢哒嗪-3（2H）-一衍生物的有效合成，抗惊厥和肌肉松弛活性
- 作者：Bhawna Sharma;Amita Verma;Upendra Kumar Sharma;Sunil Prajapati
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第1期
- Anticonvulsant;
- Convulsion;
- Aryl pyridazinone;
- MES model;
- PTZ model;
- Muscle relaxant activity;
94.Structure-function prediction of alpha_(2A)-, alpha_(2B)-, and alpha_(2C)-adrenoceptors using homology model assisted antagonist binding study

机译：使用同源模型辅助拮抗剂结合研究预测alpha_（2A）-，alpha_（2B）-和alpha_（2C）-肾上腺素受体的结构功能
- 作者：Vivek Kumar;Gourja Bansal;Jignesh Patel;C. Gopi Mohan
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第2期
- alpha_2-Adrenoceptor;
- Homology modeling;
- Molecular docking;
- Glide;
- Antagonist;
95.Molecular docking, QSAR and AMDET analysis of 6-methyl-l,3,8-trichlorodibenzofuran and its analogs against Estrogen receptor alpha

机译：6-甲基-1,3,8-三氯二苯并呋喃及其类似物对雌激素受体α的分子对接，QSAR和AMDET分析
- 作者：C. Kumaraswamy Naidu;Y. Suneetha
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第11期
- Estrogen receptor alpha;
- 6-methyl-l;
- 3;
- 8-trichlorodibenzofuran;
- Virtual screening;
- Docking;
96.Elaborate ligand-based modeling reveals new human neutrophil elastase inhibitors

机译：基于配体的精细建模揭示了新的人类嗜中性粒细胞弹性蛋白酶抑制剂
- 作者：Maha Habash;Ahmed H. Abdelazeem;Mutasem O. Taha
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第8期
97.Spectroscopic, antiproliferative and antiradical properties of Cu(II), Ni(II), and Zn(II) complexes with amino acid based Schiff bases

机译：具有氨基酸基席夫碱的Cu（II），Ni（II）和Zn（II）配合物的光谱，抗增殖和抗自由基性能
- 作者：Zuhal Karagoz Gene;Sibel Selcuk;Suleyman Sal;Naki Colak;Serhat Keser;Memet Sekerci;Mustafa Karatepe
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第5期
- Spectroscopy;
- Schiff base;
- Antiproliferative activity;
- DPPH;
98.Molecular modeling studies of substituted 3,4-dihydroxychalcone derivatives as 5-lipoxygenase and cyclooxygenase inhibitors

机译：取代的3,4-二羟基查耳酮衍生物作为5-脂氧合酶和环氧合酶抑制剂的分子模型研究
- 作者：Mukesh C. Sharma
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第4期
- Chalcone;
- 2D-QSAR;
- Group based QSAR;
- kappa-Nearest Neighbor;
- Pharmacophore;
- 5-Lipoxygenase;
- Cyclooxygenase inhibitors;
99.Synthesis, characterization and antimicrobial studies of a few novel thiazole derivatives

机译：几种新型噻唑衍生物的合成，表征和抗菌研究
- 作者：Aletti S. Praveen;Hemmige S. Yathirajan;Badiadka Narayana;Balladka K. Sarojini
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第1期
- Hantzsch thiazoles synthesis;
- Fischer esterification;
- T_3P;
- Antibacterial activity;
- Antifungal activity;
100.Quantitative structure-property relationship study on the intercalation of anticancer drugs with ct-DNA

机译：ct-DNA嵌入抗癌药物的定量构效关系研究
- 作者：Shahin Ahmadi;Mohammad Reza Khazaei;Azize Abdolmaleki
- 期刊名称：《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 | 2014年第3期
- QSPR;
- Anticancer;
- DNA intercalation;
- SOM;
- GA-MLR;
- RHM;

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