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首页> 外文期刊>Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents >Chemical composition of Hypogymnia physodes lichen and biological activities of some its major metabolites
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Chemical composition of Hypogymnia physodes lichen and biological activities of some its major metabolites

机译：失眠的地衣的化学成分及其主要代谢产物的生物活性

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The aim of this study is to investigate chemical composition of acetone extract of the lichen Hypogymnia physodes and antioxidant, -microbial, and -cancer activities of some its major metabolites. Four depsidones (fumarprot-ocetraric-, 3-hydroxyphysodalic-, physodalic-, and physodic acids), two depsides (atranorin and chloroatranorin), and usnic acid were identified from the lichen H. physodes growing in Serbia using high-performance liquid chroma-tography with photodiode array detector. Antioxidant activity of isolated metabolites was evaluated by free radical scavenging, superoxide anion radical scavenging, and reducing power. As a result of this study physodic acid was found to have stronger antioxidant activities. The antimicrobial activity was estimated by determination of the minimal inhibitory concentration by the broth microdilution method. All isolated compounds were highly active with minimum inhibitory concentration values ranging from 0.0008 to 1 mg/ ml. Anticancer activity was tested against FemX (human melanoma) and LS 174 (human colon carcinoma) cell lines using microculture tetrazolium method. Tested compounds were found have strong anticancer activity toward both cell lines with IC_(50) values ranging from 12.72 ± 0.35 to 24.63 ±2.15 mug/ml. The present study shows that isolated lichen compounds demonstrated strong antioxidant, -microbial, and -cancer effects. The results suggest that this lichen can be used as new sources of the natural antimicrobial agents, antioxidants, and -cancer compounds.
机译：这项研究的目的是调查地衣败血症丙酮的丙酮提取物的化学组成以及其主要代谢产物的抗氧化，抗微生物和抗癌活性。使用高效液相色谱仪从塞尔维亚生长的地衣藻中鉴定出了四种de烯（富马普酸，3-羟基硫代磷酸，植酸和植酸），两种two杂（阿特拉诺林和氯阿特拉诺林）和松萝酸。光电二极管阵列检测器进行成像。通过自由基清除，超氧阴离子自由基清除和还原能力评估分离出的代谢产物的抗氧化活性。这项研究的结果是发现植酸具有更强的抗氧化活性。通过用肉汤微量稀释法测定最小抑菌浓度来评估抗菌活性。所有分离的化合物均具有高活性，最小抑菌浓度范围为0.0008至1 mg / ml。使用微培养四唑法测试了针对FemX（人类黑色素瘤）和LS 174（人类结肠癌）细胞系的抗癌活性。发现测试化合物对两种细胞系均具有很强的抗癌活性，IC_（50）值范围为12.72±0.35至24.63±2.15 mug / ml。本研究表明，分离出的地衣化合物具有较强的抗氧化，抗微生物和抗癌作用。结果表明该地衣可用作天然抗微生物剂，抗氧化剂和癌症化合物的新来源。

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