Synthesis of novel fluoro 1,2,3-triazole tagged amino bis(benzothiazole) derivatives, their antimicrobial and anticancer activity

Ravindra M. Kumbhare; Tulshiram L. Dadmal; R. Pamanji; Umesh B. Kosurkar; L. R. Velatooru; K. Appalanaidu; Y. Khageswara Rao; J. Venkateswara Rao

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Synthesis of novel fluoro 1,2,3-triazole tagged amino bis(benzothiazole) derivatives, their antimicrobial and anticancer activity

机译：新型含氟1,2,3-三唑标记的氨基双（苯并噻唑）衍生物的合成，抗菌和抗癌活性

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A new series of fluoro 1,2,3-triazole tagged amino bis (benzothiazole) derivatives 8, 9 were prepared starting from 2-amino benzothiazole in four steps via amination, cyclization, alkylation followed by reaction with various azides under sharpless conditions through click chemistry approach. All newly synthesized compounds were screened for their antimicrobial and cytotoxic activity against four human cancer cell lines (U937, THP-1, Colo205, and A549), and promising compounds have been identified.

机译：从2-氨基苯并噻唑开始，经胺化，环化，烷基化，分四个步骤从2-氨基苯并噻唑开始，制备了一系列新的含氟1,2,3-三唑标记的氨基双（苯并噻唑）衍生物8、9，然后在无尖锐条件下通过点击反应与各种叠氮化物反应化学方法。筛选了所有新合成的化合物对四种人类癌细胞系（U937，THP-1，Colo205和A549）的抗微生物和细胞毒性活性，并鉴定了有前途的化合物。

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《Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents》 |2014年第10期|共10页
作者
Ravindra M. Kumbhare; Tulshiram L. Dadmal; R. Pamanji; Umesh B. Kosurkar; L. R. Velatooru; K. Appalanaidu; Y. Khageswara Rao; J. Venkateswara Rao;
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正文语种 eng
中图分类药学;
关键词
Amino bis (benzothiazole); 2-amino benzothiazole; Sharpless conditions; Antibacterial activity; Antifungal activity; Anticancer activity;

机译：氨基双（苯并噻唑）;2-氨基苯并噻唑;无尖锐条件;抗菌活性;抗真菌活性;抗癌活性;

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1. Synthesis of novel fluoro 1,2,3-triazole tagged amino bis(benzothiazole) derivatives, their antimicrobial and anticancer activity [J] . Ravindra M. Kumbhare, Tulshiram L. Dadmal, R. Pamanji, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2014,第10期

机译：新型含氟1,2,3-三唑标记的氨基双（苯并噻唑）衍生物的合成，抗菌和抗癌活性
2. Synthesis of Novel 1,2,3-Triazole/Isoxazole-Functionalized Imidazo[4,5-b]pyridin-2(3H)-one Derivatives, Their Antimicrobial and Anticancer Activity [J] . Banda Veeraswamy, Gautham Santhosh Kumar, Pillalamarri Sambasiva Rao, Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 2016,第4期

机译：新型1,2,3-三唑/异恶唑官能化的咪唑并[4,5-b]吡啶-2（3H）-one衍生物的合成及其抗菌和抗癌活性
3. One-pot synthesis and biological evaluation of novel 4-[3-fluoro-4-(morpholin-4-yl)]phenyl-1H-1,2,3-triazole derivatives as potent antibacterial and anticancer agents [J] . Narsimha Sirassu, Nukala Sathesh Kumar, Jyostna T. Savitha, Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 2020,第4期

机译：一种新的4- [3-氟-4-（吗啉-4-基）]苯基-1H-1,2,3-三唑衍生物作为有效的抗菌和抗癌剂的单壶合成及生物学评价
4. Synthesis and characterization of 1-amino-4-nitro-1,2,3-triazole and 2-amino-4-nitro-1,2,3-triazole [C] . Dominique R. Wozniak, Benjamin Salfer, Matthias Zeller, . 2020

机译：1-氨基-4-硝基-1,2,3-三唑和2-氨基-4-硝基-1,2,3-三唑的合成与表征
5. Synthesis of evaluation of beta-glycosyl-1,2,3-triazole derivatives as beta-glycosidase inhibitors. [D] . Rossi, Lauren Lucille. 2007

机译：合成评价β-糖基-1,2,3-三唑衍生物作为β-糖苷酶抑制剂。
6. Synthesis of novel Schiff bases using 2-Amino-5-(3-fluoro-4-methoxyphenyl)thiophene-3-carbonitrile and 13-Disubstituted pyrazole-4-carboxaldehydes derivatives and their antimicrobial activity [O] . Divyaraj Puthran, Boja Poojary, Nikil Purushotham, 2019

机译：使用2-氨基-5-（3-氟-4-甲氧基苯基）噻吩-3-腈和13-二取代吡唑-4-羧醛衍生物的新型席夫碱的合成及其抗菌活性
7. Design, synthesis, anticancer activity and docking studies of theophylline containing 1,2,3-triazoles with variant amide derivatives [O] . Radhakrishnam Raju Ruddarraju, Adharvana Chari Murugulla, Ravindar Kotla, 2017

机译：含1,2,3-三唑与变体酰胺衍生物的茶碱的设计，合成，抗癌活动和对接研究
8. Synthesis, Characterization, and Structural Investigations of 1-amino-3-Substituted- 1,2,3-Triazolium Salts, and a New Route to 1-substituted-1,2,3- triazoles [R] . Kaplan, G. , Drake, G. , Tollison, K. , 2004

机译：1-氨基-3-取代-1,2,3-三唑盐的合成，表征和结构研究，以及1-取代-1,2,3-三唑的新途径

Synthesis of novel fluoro 1,2,3-triazole tagged amino bis(benzothiazole) derivatives, their antimicrobial and anticancer activity

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