• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemotherapy Research and Practice >Anti-Inflammatory Cytokines: Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis
【24h】

Anti-Inflammatory Cytokines: Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis

机译：抗炎性细胞因子：导致化疗引起的胃肠道粘膜炎的重要免疫调节因素

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

“Mucositis” is the clinical term used to describe ulceration and damage of the mucous membranes of the entire gastrointestinal tract (GIT) following cytotoxic cancer chemotherapy and radiation therapy common symptoms include abdominal pain, bloating, diarrhoea, vomiting, and constipation resulting in both a significant clinical and financial burden. Chemotherapeutic drugs cause upregulation of stress response genes includingNFκB,that in turn upregulate the production of proinflammatory cytokines such as interleukin-1β(IL-1β), Interleukin-6 (IL-6), and tumour necrosis factor-α(TNF-α). These proinflammatory cytokines are responsible for initiating inflammation in response to tissue injury. Anti-inflammatory cytokines and specific cytokine inhibitors are also released to limit the sustained or excessive inflammatory reactions. In the past decade, intensive research has determined the role of proinflammatory cytokines in development of mucositis. However, a large gap remains in the knowledge of the role of anti-inflammatory cytokines in the setting of chemotherapy-induced mucositis. This critical paper will highlight current literature available relating to what is known regarding the development of mucositis, including the molecular mechanisms involved in inducing inflammation particularly with respect to the role of proinflammatory cytokines, as well as provide a detailed discussion of why it is essential to consider extensive research in the role of anti-inflammatory cytokines in chemotherapy-induced mucositis so that effective targeted treatment strategies can be developed.
机译：“粘膜炎”是临床术语，用于描述细胞毒性癌化学疗法和放射疗法后整个胃肠道（GIT）的溃疡和破损，常见症状包括腹痛，腹胀，腹泻，呕吐和便秘，导致重大的临床和财务负担。化学治疗药物导致包括NFκB在内的应激反应基因上调，从而反过来上调促炎细胞因子的生成，例如白介素-1β（IL-1β），白介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）。 。这些促炎细胞因子负责响应组织损伤而引发炎症。抗炎细胞因子和特定的细胞因子抑制剂也被释放以限制持续或过度的炎症反应。在过去的十年中，深入的研究确定了促炎细胞因子在粘膜炎发展中的作用。但是，关于抗炎细胞因子在化学疗法诱发的粘膜炎中的作用的认识仍然存在很大差距。这篇重要论文将重点介绍与粘膜炎发展相关的现有文献，包括诱发炎症的分子机制，特别是促炎性细胞因子的作用，并就其为何对炎症至关重要。考虑在抗炎细胞因子在化疗诱导的粘膜炎中的作用方面进行广泛的研究，以便开发出有效的靶向治疗策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号