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A primer on the mouse basal body

机译：小鼠基体上的底漆

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The basal body is a highly organized structure essential for the formation of cilia. Basal bodies dock to a cellular membrane through their distal appendages (also known as transition fibers) and provide the foundation on which the microtubules of the ciliary axoneme are built. Consequently, basal body position and orientation dictates the position and orientation of its cilium. The heart of the basal body is the mother centriole, the older of the two centrioles inherited during mitosis?and which is comprised of nine triplet microtubules arranged in a cylinder. Like all ciliated organisms, mice possess basal bodies, and studies of mouse basal body structure have made diverse important contributions to the understanding of how basal body structure impacts the function of cilia. The appendages and associated structures?of mouse basal bodies can differ in their architecture from those of other organisms, and even between murine cell types. For example, basal bodies of immotile primary cilia are connected to daughter centrioles, whereas those of motile multiciliated cells are not. The last few years have seen the identification of many components of the basal body, and the mouse will continue to be an extremely valuable system for genetically defining their functions.
机译：基体是纤毛形成必不可少的高度组织的结构。基体通过其远端附属物（也称为过渡纤维）对接至细胞膜，并为建立纤毛轴突微管的基础提供了基础。因此，基础身体的位置和方向决定了其纤毛的位置和方向。基体的心脏是母中心，这是有丝分裂过程中遗传的两个中心中的老者，它由排列在圆柱体中的九个三联体微管组成。像所有纤毛生物一样，小鼠具有基体，并且对小鼠基体结构的研究对理解基体结构如何影响纤毛功能做出了多种重要贡献。小鼠基体的附肢和相关结构在结构上可能与其他生物体不同，甚至在鼠细胞类型之间也可能不同。例如，不活动的初级纤毛的基体连接到子中心，而活动的多纤毛细胞的基体则不连接。在过去的几年中，已经鉴定出了基体的许多组成部分，而鼠标将继续成为遗传定义其功能的极有价值的系统。

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