CILIA: before and after

Peter Satir

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CILIA: before and after

机译：西莉亚：之前和之后

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This is a history of cilia research before and after the discovery of intraflagellar transport (IFT) and the link between primary cilia ciliogenesis and polycystic kidney disease (PKD). Before IFT, ca. the beginning of the new millennium, although sensory and primary cilia were well described, research was largely focused on motile cilia, their structure, movement, and biogenesis. After IFT and the link to PKD, although work on motile cilia has continued to progress, research on primary cilia has exploded, leading to new insights into the role of cilia in cell signaling and development. Genomics, proteomics, and new imaging techniques have unified the field and pointed out the critical role of cilia as a restricted cell organellar compartment, functionally integrated with other cell organelles including the autophagosome and the nucleus.

机译：这是发现鞭毛内转运（IFT）之前和之后以及原发性纤毛纤毛发生与多囊肾疾病（PKD）之间的联系的纤毛研究的历史。在IFT之前，在新千年的开始，尽管对感觉纤毛和原发性纤毛已有很好的描述，但研究主要集中于活动纤毛，其结构，运动和生物发生。在IFT和与PKD的联系之后，尽管有关活动纤毛的研究仍在继续进行，但有关原发纤毛的研究却出现了爆炸式增长，从而使人们对纤毛在细胞信号传导和发育中的作用有了新的认识。基因组学，蛋白质组学和新的成像技术统一了该领域，并指出纤毛作为限制性细胞器腔室的关键作用，功能上与其他细胞器（包括自噬体和细胞核）功能整合。

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《Cilia》 |2017年第1期|共页
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Peter Satir;
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中图分类细胞生物学;
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1. Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia [J] . Livana Soetedjo, Hua Jin, DeVona A. Glover Biology Open . 2014,第11期

机译：将血管活性肠肽受体2，VPAC2，一种分泌素家族G蛋白偶联受体靶向初级纤毛将血管活性肠肽受体2，VPAC2，一种分泌素家族G蛋白偶联受体，靶向初级纤毛2，原发性纤毛的促胰液素家族G蛋白偶联受体VPAC2
2. Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia [J] . Livana Soetedjo, Hua Jin, DeVona A. Glover Biology Open . 2013,第7期

机译：将血管活性肠肽受体2，VPAC2，一种分泌素家族G蛋白偶联受体靶向初级纤毛将血管活性肠肽受体2，VPAC2，一种分泌素家族G蛋白偶联受体，靶向初级纤毛2，原发性纤毛的促胰液素家族G蛋白偶联受体VPAC2
3. CPAP is required for cilia formation in neuronal cells CPAP is required for cilia formation in neuronal cells CPAP is required for cilia formation in neuronal cells [J] . Kuo-Sheng Wu, Tang K. Tang Biology Open . 2012,第6期

机译：CPAP是神经细胞中纤毛形成所必需的CPAP是神经细胞中纤毛形成所必需的CPAP是神经细胞中纤毛形成所必需的
4. Model-Based Control Can Improve the Performance of Artificial Cilia [C] . Edoardo Milana, Francesco Stella, Benjamin Gorissen, IEEE International Conference on Soft Robotics . 2021

机译：基于模型的控制可以提高人工纤毛的性能
5. The Structure of Sperm Autoantigenic Protein (SPA17): An R2D2 Protein Critical to Cilia and Implicated in Oncogenesis [D] . Dahlin, Heather Raquel. 2021

机译：精子自身抗原蛋白（SPA17）的结构：对纤毛至关重要的R2D2蛋白，涉及一种诱发性
6. Primary cilia utilize glycoprotein-dependent adhesion mechanisms to stabilize long-lasting cilia-cilia contacts [O] . Carolyn Ott, Natalie Elia, Suh Young Jeong, 2012

机译：原发性纤毛利用糖蛋白依赖性粘附机制来稳定持久的纤毛与纤毛接触
7. Primary cilia utilize glycoprotein-dependent adhesion mechanisms to stabilize long-lasting cilia-cilia contacts [O] . Carolyn Ott, Natalie Elia, Suh Jeong, 2012

机译：原发性纤毛利用糖蛋白依赖性粘附机制来稳定持久的纤毛与纤毛接触

CILIA: before and after

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