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首页> 外文期刊>Chronic respiratory disease. >Diffusion capacity of the lung for carbon monoxide – A potential marker of impaired gas exchange or of systemic deconditioning in chronic obstructive lung disease?
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Diffusion capacity of the lung for carbon monoxide – A potential marker of impaired gas exchange or of systemic deconditioning in chronic obstructive lung disease?

机译：肺对一氧化碳的扩散能力–慢性阻塞性肺疾病中气体交换受损或系统性退化的潜在标志？

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Gas exchange impairment is primarily caused by ventilation–perfusion mismatch in chronic obstructive pulmonary disease (COPD), where diffusing capacity of the lungs for carbon monoxide (DLCO) remains the clinical measure. This study investigates whether DLCO: (1) can predict respiratory impairment in COPD, that is, changes in oxygen and carbon dioxide (CO2); (2) is associated with combined risk assessment score for COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) score); and (3) is associated with blood glucose and body mass index (BMI). Fifty patients were included retrospectively. DLCO; arterial blood gas at inspired oxygen (FiO2) = 0.21; oxygen saturation (SpO2) at FiO2 = 0.21 (SpO2 21) and FiO2 = 0.15 (SpO2 15) were registered. Difference between arterial and end-tidal CO2 (ΔCO2) was calculated. COPD severity was stratified according to GOLD score. The association between DLCO, SpO2, ΔCO2, GOLD score, blood glucose, and BMI was investigated. Multiple regression showed association between DLCO and GOLD score, BMI, and glucose level (R 2 = 0.6, p < 0.0001). Linear and multiple regression showed an association between DLCO and SpO2 21 (R 2 = 0.3, p = 0.001 and p = 0.03, respectively) without contribution from SpO2 15 or ΔCO2. A stronger association between DLCO and GOLD score than between DLCO and SpO2 could indicate that DLCO is more descriptive of systemic deconditioning than gas exchange in COPD patients. However, further larger studies are needed. A weaker association is seen between DLCO and SpO2 21 without contribution from SpO2 15 and ΔCO2. This could indicate that DLCO is more descriptive of systemic deconditioning than gas exchange in COPD patients. However, further larger studies are needed.
机译：气体交换障碍主要是由慢性阻塞性肺疾病（COPD）中的通气-灌注不匹配引起的，其中肺对一氧化碳的扩散能力（DLCO）仍是临床措施。这项研究调查了DLCO是否：（1）可以预测COPD的呼吸功能障碍，即氧气和二氧化碳（CO2）的变化; （2）与COPD的综合风险评估得分（全球慢性阻塞性肺疾病倡议（GOLD）得分）相关; （3）与血糖和体重指数（BMI）相关。回顾性纳入50例患者。 DLCO;吸入氧气（FiO2）时的动脉血气= 0.21;记录下FiO2 = 0.21（SpO2 21）和FiO2 = 0.15（SpO2 15）的氧饱和度（SpO2）。计算了动脉和潮气末CO2之间的差异（ΔCO2）。根据GOLD评分将COPD严重程度分层。研究了DLCO，SpO2，ΔCO2，GOLD评分，血糖和BMI之间的关联。多元回归显示DLCO与GOLD评分，BMI和血糖水平之间存在关联（R 2 = 0.6，p <0.0001）。线性回归和多元回归显示DLCO和SpO2 21之间的关联（R 2 = 0.3，p = 0.001和p = 0.03，分别），而SpO2 15或ΔCO2则无贡献。 DLCO和GOLD评分之间的关​​联比DLCO和SpO2之间的关联更强，这表明DLCO在COPD患者中比抽气更能说明系统性疾病。但是，还需要进一步的研究。没有SpO2 15和ΔCO2的贡献，DLCO和SpO2 21之间的关联较弱。这可能表明在COPD患者中，DLCO比全身气体置换更能说明系统性疾病。但是，还需要进一步的研究。

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