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首页> 外文期刊>Chronic Wound Care Management and Research >Pressure ulcer treatment in a long-term care setting: wound bed healing with clostridial collagenase ointment versus hydrogel dressing
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Pressure ulcer treatment in a long-term care setting: wound bed healing with clostridial collagenase ointment versus hydrogel dressing

机译：长期护理中的压疮治疗：使用梭菌胶原酶软膏与水凝胶敷料进行创口愈合

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Purpose: To compare clinical outcomes in patients with pressure ulcers (PUs) who were treated with enzymatic debridement using clostridial collagenase ointment (CCO) with those treated with autolytic debridement using a hydrogel dressing. Patients and methods: This prospective, randomized, blinded, single-site trial directly compared the use of CCO and hydrogel dressings for treatment of PUs in patients in a long-term care facility. Changes in wound bed scores (WBS), tissue granulation, wound surface area, and epithelialization were assessed weekly during the 6-week treatment. Effects of treatment time, treatment method, and the combination of treatment time and method on continuous outcomes were analyzed by linear regression; the effects of covariates on epithelialization were analyzed by logistic regression. Results: Overall, 27 patients completed the study; 13 patients were treated with CCO and 14 with hydrogel. Baseline demographic and clinical characteristics were similar between the treatment groups. Patients treated with CCO had a granulation rate approximately twice that of those receiving hydrogel and showed a significantly higher rate of granulation tissue formation at week 6. Treatment duration and the combination of treatment duration and method were significant predictors of granulation tissue formation. WBS improvements from baseline to week 6 were greater in patients who received CCO than in those treated with hydrogel (+4.6 units versus +2.6 units, respectively). Treatment duration and the combination of treatment duration and method were predictors of WBS improvement. Patients treated with CCO showed significant reductions in wound surface area from baseline (10.3 cm2) to week 6 (2.1 cm2). At week 6, epithelialization was numerically higher in patients treated with CCO than in patients treated with hydrogel. Conclusion: Long-term care facility patients with PUs who received enzymatic debridement with CCO had greater improvements in granulation tissue formation, WBS, wound surface area, and wound closure than did those treated with hydrogel.
机译：目的：比较使用梭状芽孢杆菌胶原酶软膏（CCO）进行酶促清创术和使用水凝胶敷料进行自溶性清创术治疗的压疮患者的临床结局。患者和方法：这项前瞻性，随机，盲法，单点试验直接比较了在长期护理机构中使用CCO和水凝胶敷料治疗患者的PU。在6周的治疗期间，每周评估伤口床评分（WBS），组织肉芽形成，伤口表面积和上皮形成的变化。通过线性回归分析治疗时间，治疗方法以及治疗时间和方法的组合对连续结果的影响。通过逻辑回归分析协变量对上皮形成的影响。结果：总共有27例患者完成了研究。 CCO治疗13例，水凝胶治疗14例。治疗组之间的基线人口统计学和临床​​特征相似。用CCO治疗的患者的肉芽形成率大约是接受水凝胶的患者的两倍，并且在第6周时显示出明显更高的肉芽组织形成率。治疗时间以及治疗时间和方法的组合是肉芽组织形成的重要预测指标。与使用水凝胶治疗的患者相比，接受CCO的患者从基线到第6周的WBS改善更大（分别为+4.6单位和+2.6单位）。治疗持续时间以及治疗持续时间和方法的组合是WBS改善的预测指标。从基线（10.3 cm 2 ）到第6周（2.1 cm 2 ），接受CCO治疗的患者的伤口表面积显着减少。在第6周，接受CCO治疗的患者的上皮形成数量高于接受水凝胶治疗的患者。结论：接受CCO酶清创术的长期护理机构PU患者比水凝胶治疗的患者在肉芽组织形成，WBS，伤口表面积和伤口闭合方面有更大的改善。

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