...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Circulation journal >Exhaled Acetone Concentration Is Related to Hemodynamic Severity in Patients With Non-Ischemic Chronic Heart Failure
【24h】

Exhaled Acetone Concentration Is Related to Hemodynamic Severity in Patients With Non-Ischemic Chronic Heart Failure

机译：非缺血性慢性心力衰竭患者呼出的丙酮浓度与血流动力学严重程度有关

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: We hypothesized that exhaled acetone concentration (EAC), reflecting altered blood ketone body metabolism and increased acetone exhaust because of pulmonary congestion in heart failure (HF), would correlate with hemodynamic parameters in patients with non-ischemic chronic HF. Methods?and?Results: We prospectively enrolled 102 non-ischemic HF patients with New York Heart Association (NYHA) class I–III. Exhaled breath was collected after an overnight fast. Echocardiography and cardiac catheterization were performed in all patients. We also enrolled 17 control patients without HF. EAC in the HF patients was significantly higher than that in the control patients (median EAC; 0.53 vs. 0.38 ppm, P=0.012). EAC positively correlated with blood total ketone bodies (r=0.454, P1.05 ppm was associated with PCWP ≥18 mmHg (area under the curve [AUC] 0.726, sensitivity 50%, specificity 89%). EAC was shown to be a comparable diagnostic biomarker for HF to BNP (AUC 0.760, sensitivity 80%, specificity 70%). Conclusions: EAC may be a novel noninvasive biomarker that correlates hemodynamic severity in non-ischemic chronic HF. ( Circ J 2016; 80: 1178–1186)
机译：背景：我们假设呼出气的丙酮浓度（EAC）反映了由于心力衰竭（HF）的肺充血引起的血酮体代谢改变和丙酮排出量增加，这与非缺血性慢性HF患者的血液动力学参数相关。方法和结果：我们前瞻性招募了102例患有非缺血性HF的纽约心脏协会（NYHA）I–III级患者。整夜禁食后呼气。所有患者均进行了超声心动图检查和心脏导管检查。我们还招募了17名无心衰的对照患者。 HF患者的EAC显着高于对照组患者（中位EAC; 0.53比0.38 ppm，P = 0.012）。 EAC与血液总酮体呈正相关（r = 0.454，​​P1.05 ppm与PCWP≥18 mmHg相关（曲线下面积[AUC] 0.726，灵敏度50％，特异性89％）。EAC具有可比性诊断为BNP的HF的生物标志物（AUC 0.760，敏感性80％，特异性70％）结论：EAC可能是一种新型的非侵入性生物标志物，与非缺血性慢性HF的血流动力学严重程度相关（Circ J 2016; 80：1178-1186）

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号