M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells

Endang Mahati; Peili Li; Yasutaka Kurata; Nani Maharani; Nobuhito Ikeda; Shinji Sakata; Kazuyoshi Ogura; Junichiro Miake; Takeshi Aiba; Wataru Shimizu; Naoe Nakasone; Haruaki Ninomiya; Katsumi Higaki; Kazuhiro Yamamoto; Akira Nakai; Yasuaki Shirayoshi; Ichiro Hisatome

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M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells

机译：M3毒蕈碱受体信号通过转染细胞中的热休克因子1的磷酸化稳定一种新型的突变人类以太去相关基因通道蛋白。

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Background: Long QT syndrome 2 (LQT2) is caused by mutations in the human ether-a-go-go-related gene ( hERG ). Most of its mutations give rise to unstable hERG proteins degraded by the proteasome. Recently, carbachol was reported to stabilize the wild-type hERG-FLAG via activation of the muscarinic type 3 receptor (M3-mAChR). Its action on mutant hERG-FLAG, however, remains uninvestigated.

机译：背景：长QT综合征2（LQT2）是由人类走走相关基因（hERG）中的突变引起的。它的大多数突变都会导致不稳定的hERG蛋白被蛋白酶体降解。最近，据报道，卡巴胆碱通过毒蕈碱型3型受体（M3-mAChR）的活化来稳定野生型hERG-FLAG。然而，其对突变型hERG-FLAG的作用尚待研究。

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《Circulation journal》 |2016年第12期|共10页
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Endang Mahati; Peili Li; Yasutaka Kurata; Nani Maharani; Nobuhito Ikeda; Shinji Sakata; Kazuyoshi Ogura; Junichiro Miake; Takeshi Aiba; Wataru Shimizu; Naoe Nakasone; Haruaki Ninomiya; Katsumi Higaki; Kazuhiro Yamamoto; Akira Nakai; Yasuaki Shirayoshi; Ichiro Hisatome;
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中图分类心脏、血管（循环系）疾病;
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1. M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells [J] . Mahati Endang, Li Peili, Kurata Yasutaka, Circulation journal . 2016,第12期

机译：M3毒蕈碱受体信号通过转染细胞中的热休克因子1的磷酸化稳定一种新型的突变人类以太去相关基因通道蛋白。
2. M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells [J] . Mahati Endang, Li Peili, Kurata Yasutaka, Circulation journal . 2016,第12期

机译：M3毒蕈碱受体信号传导通过在转染细胞中通过磷酸化稳定一种新型突变人醚-A-α-致新相关基因通道蛋白
3. Stimulation of N-terminal truncated isoform of androgen receptor stabilizes human ether-a-go-go-related gene-encoded potassium channel protein via activation of extracellular signal regulated kinase 1/2. [J] . Wu ZY, Chen K, Haendler B, Endocrinology . 2008,第10期

机译：刺激雄激素受体的N端截短同工型通过激活细胞外信号调节激酶1/2来稳定人类与人为相关的基因编码的钾通道蛋白。
4. Injury and stimulation of Porcine Aortic Endothelial cells (PAE) with nucleotides or EGF result in differential phosphorylation of epidermal growth factor receptor (EGFR) and affect recruitment of the downstream signaling protein Grb2 [C] . Amanuel Y. Kehasse, Giuseppe Infusini, Ilene Boucher, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：猪主动脉内皮细胞（PAE）与核苷酸或EGF的损伤和刺激导致表皮生长因子受体（EGFR）的差异磷酸化，并影响下游信号蛋白GRB2的募集
5. Heat shock transcription factor 1 and heat shock protein 72 play a critical role in HER2-induced cellular transformation and tumorigenesis [D] . Meng, Le 2012

机译：热休克转录因子1和热休克蛋白72在HER2诱导的细胞转化和肿瘤发生中起关键作用
6. Heat shock factor-1 protein in heat shock factor-1 gene-transfected human epidermoid A431 cells requires phosphorylation before inducing heat shock protein-70 production. [O] . X Z Ding, G C Tsokos, J G Kiang 1997

机译：热休克因子-1基因转染的人表皮样A431细胞中的热休克因子1蛋白需要磷酸化才能诱导热休克蛋白70的产生。
7. M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells [O] . Endang Mahati, Peili Li, Yasutaka Kurata, 2016

机译：M3毒蕈碱受体信号传导通过在转染细胞中通过磷酸化稳定一种新型突变人醚-A-α-致新相关基因通道蛋白
8. Use of a Transfected and Amplified Drosophila Heat Shock Promoter Construction for Inducible Production of Toxic Mouse C-Myc Proteins in CHO Cells [R] . Wurm, F. M. , Gwinn, K. A. , Papoulas, O. , 1987

机译：使用转染和扩增果蝇热休克启动子构建诱导CHO细胞中毒性小鼠C-myc蛋白的生成

M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells

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