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首页> 外文期刊>Circulation journal >High Citrulline-to-Arginine Ratio Associated With Blood Pressure Abnormalities in Children With Early Chronic Kidney Disease
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High Citrulline-to-Arginine Ratio Associated With Blood Pressure Abnormalities in Children With Early Chronic Kidney Disease

机译：早期慢性肾脏病患儿的瓜氨酸/精氨酸比高与血压异常相关

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Background: ?Nitric oxide (NO) is involved in hypertension and chronic kidney disease (CKD). NO synthase can metabolize L-arginine (ARG) to generate NO and L-citrulline (CIT). Two methylated ARG derivatives, asymmetric and symmetric dimethylarginine, are also involved in NO deficiency. Thus it was hypothesized that their combined ratios relate to blood pressure (BP) abnormalities in children with early CKD. Methods and Results: ?The relationship between these ARG metabolites in plasma was examined using 24-h ambulatory BP monitoring (ABPM) profile in children and adolescents with CKD stages 1–3 (n=44). Approximately 20.4% (9/44) of children with CKD stages 1–3 were diagnosed with hypertension on clinical BP measurement, and 77.3% (33/44) had BP abnormalities on ABPM, including increased BP load, nocturnal BP non-dipping, and nocturnal hypertension. Children with CKD stages 2–3 were more prevalent with abnormal BP on ABPM, and had a higher level of CIT and CIT-to-ARG ratio than those with stage 1. Furthermore, high CIT-to-ARG ratio was significantly correlated with abnormal ABPM profile, including nocturnal hypertension, increased diastolic BP load, and nocturnal BP non-dipping. Higher CIT level was significantly correlated with increased diastolic BP load and overall ABPM profile. Conclusions: ?Plasma CIT-to-ARG ratio may serve as a useful marker of cardiovascular outcome in children with early CKD.??(Circ J?2013; 77: 181–187)
机译：背景：一氧化氮（NO）与高血压和慢性肾脏病（CKD）有关。 NO合酶可以代谢L-精氨酸（ARG）生成NO和L-瓜氨酸（CIT）。 NO缺乏也涉及两种甲基化的ARG衍生物，即不对称和对称的二甲基精氨酸。因此，假设他们的合并比率与早期CKD儿童的血压（BP）异常有关。方法和结果：？使用CKD 1-3期（n = 44）的儿童和青少年，使用24小时动态BP监测（ABPM）分析了血浆中这些ARG代谢物之间的关系。在临床BP测量中，约20.4％（9/44）的CKD 1-3期儿童被诊断出患有高血压，而ABPM上的BP异常为77.3％（33/44），包括BP负荷增加，夜间BP不浸尿，和夜间高血压。 CKD 2–3期儿童的ABPM血压异常更为普遍，并且CIT和CIT / ARG的水平高于1期儿童。此外，高CIT / ARG的比例与异常有关。 ABPM资料，包括夜间高血压，舒张期BP负荷增加和夜间BP不浸入。较高的CIT水平与舒张压增加和总体ABPM曲线显着相关。结论：血浆CIT与ARG之比可能是早期CKD患儿心血管预后的有用指标。（Circ J？2013; 77：181–187）

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